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MDPV: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
MDPV, or 3,4-Methylenedioxypyrovalerone, is a synthetic stimulant of the [[substituted cathinone|cathinone]] and [[substituted pyrrolidine|pyrrolidine]] classes. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound [[a-PVP]], developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence.<ref>US Patent 3478050 - 1-(3',4'-methylenedioxy-phenyl)-2-pyrrolidino-alkanones-(1) | https://www.google.com/patents/US3478050</ref> However, despite some shared structural features, the effects of MDPV bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine ([[MDMA]]), instead producing primarily classical stimulant effects with only mild entactogenic qualities.<ref>MDPV | https://wiki.tripsit.me/wiki/MDPV</ref> | MDPV, or 3,4-Methylenedioxypyrovalerone, is a synthetic stimulant of the [[substituted cathinone|cathinone]] and [[substituted pyrrolidine|pyrrolidine]] classes. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound [[a-PVP]], developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence.<ref>US Patent 3478050 - 1-(3',4'-methylenedioxy-phenyl)-2-pyrrolidino-alkanones-(1) | https://www.google.com/patents/US3478050</ref> However, despite some shared structural features, the effects of MDPV bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine ([[MDMA]]), instead producing primarily classical stimulant effects with only mild entactogenic qualities.<ref>MDPV | https://wiki.tripsit.me/wiki/MDPV</ref> | ||
MDPV is structurally related to cathinone, an active alkaloid found in the khat plant, 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine, and other schedule I phenethylamines. MDPV, like some other substances in this class, is a central nervous system (CNS) stimulant. MDPV is also reported to have hallucinogenic effects.<ref>https://www.deadiversion.usdoj.gov/drug_chem_info/mdpv.pdf</ref> | |||
==Pharmacology== | ==Pharmacology== | ||
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*'''Denmark''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | *'''Denmark''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | ||
*'''Estonia ''': MDPV is a controlled substance as of November 29, 2010.<ref name="EMCDDA"></ref> | *'''Estonia ''': MDPV is a controlled substance as of November 29, 2010.<ref name="EMCDDA"></ref> | ||
*'''Finland''': MDPV is specifically listed as a controlled substance in Finland (listed appendix IV substance as of June 28, 2010),<ref>Finlex: huumausaineina pidettävistä aineista, valmisteista ja kasveista annetun valtioneuvoston asetuksen liitteen IV muuttamisesta | http://www.finlex.fi/fi/laki/alkup/2010/20100596</ref> | *'''Finland''': MDPV is specifically listed as a controlled substance in Finland (listed appendix IV substance as of June 28, 2010),<ref>Finlex: huumausaineina pidettävistä aineista, valmisteista ja kasveista annetun valtioneuvoston asetuksen liitteen IV muuttamisesta | http://www.finlex.fi/fi/laki/alkup/2010/20100596</ref> | ||
*'''France''': MDPV is a controlled substance as of August 2, 2012.<ref name="EMCDDA"></ref> | *'''France''': MDPV is a controlled substance as of August 2, 2012.<ref name="EMCDDA"></ref> | ||
*'''Germany''': MDPV is controlled under Anlage II BtMG (''Narcotics Act, Schedule II'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html|title=Anlage II BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref> as of July 26, 2012.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl112s1639.pdf|title=Sechsundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften|publisher=Bundesanzeiger Verlag|access-date=December 19, 2019|language=de}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=§ 29 BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref> | *'''Germany''': MDPV is controlled under Anlage II BtMG (''Narcotics Act, Schedule II'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html|title=Anlage II BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref> as of July 26, 2012.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl112s1639.pdf|title=Sechsundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften|publisher=Bundesanzeiger Verlag|access-date=December 19, 2019|language=de}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=§ 29 BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref> | ||
*'''Hungary''': MDPV a Schedule A controlled psychotropic substance.<ref name="EMCDDA"></ref> | *'''Hungary''': MDPV a Schedule A controlled psychotropic substance.<ref name="EMCDDA"></ref> | ||
*'''Ireland''': MDPV is covered by the Misuse of Drugs Acts since May 11, 2010.<ref name="EMCDDA"></ref> | *'''Ireland''': MDPV is covered by the Misuse of Drugs Acts since May 11, 2010.<ref name="EMCDDA"></ref> | ||
*'''Italy''': MDPV is a controlled substance as of December 29, 2011.<ref name="EMCDDA"></ref> | *'''Italy''': MDPV is a controlled substance as of December 29, 2011.<ref name="EMCDDA"></ref> | ||
*'''Latvia''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | *'''Latvia''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | ||
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*'''Norway''': MDPV is a controlled substance as of Febuary 14, 2013.<ref name="EMCDDA"></ref> | *'''Norway''': MDPV is a controlled substance as of Febuary 14, 2013.<ref name="EMCDDA"></ref> | ||
*'''Poland''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | *'''Poland''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | ||
*'''Slovakia''': MDPV a Schedule I controlled psychotropic substance as of March 1, 2011.<ref name="EMCDDA"></ref> | *'''Slovakia''': MDPV a Schedule I controlled psychotropic substance as of March 1, 2011.<ref name="EMCDDA"></ref> | ||
*'''Slovenia''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | *'''Slovenia''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> | ||
*'''Sweden''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> In Sweden a 33-year-old man has been sentenced to six years in prison by an appellate court, Hovrätt, for possession of 250 grams of MDPV that had been acquired prior to criminalization.<ref>Hovrätten skärper straff i MDPV-dom | http://www.nt.se/nyheter/?articleid=6057819</ref> | *'''Sweden''': MDPV is a controlled substance.<ref name="EMCDDA"></ref> In Sweden a 33-year-old man has been sentenced to six years in prison by an appellate court, Hovrätt, for possession of 250 grams of MDPV that had been acquired prior to criminalization.<ref>Hovrätten skärper straff i MDPV-dom | http://www.nt.se/nyheter/?articleid=6057819</ref> | ||