DPT: Difference between revisions

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~~DPT's [[psychedelic]] effects are believed to come from its efficacy at~~ the ~~[[Serotonin#The~~ 5-HT ~~system|~~5-HT2A~~]] and [[Serotonin#The~~ 5-HT ~~system|~~5-HT1A~~]] [[receptor]] as a [[Agonist#Agonists|partial agonist]]~~.<ref>~~{{cite journal|last1=Fantegrossi|first1=W. E.|last2=~~Reissig~~|first2=C. J.|last3=~~Katz~~|first3=E. B.|last4=~~Yarosh~~|first4=H. L.|last5=~~Rice~~|first5=K. C.|last6=~~Winter~~|first6=J. C~~.~~|title=~~Hallucinogen-like effects of ''N'',''N''-dipropyltryptamine (DPT): ~~Possible~~ mediation by serotonin 5-~~HT1A~~ and 5-~~HT2A~~ receptors in rodents~~|journal=~~Pharmacology Biochemistry and Behavior~~|volume=~~88~~|issue=~~3~~|pages=358-365|~~doi=10.1016/j.pbb.2007.09.007~~|pmid=~~17905422~~|pmc=2322878|issn=0091-3057|oclc= 848182005}}~~</ref>

Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.<ref>antegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC (January 2008). "Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents". ''Pharmacology, Biochemistry, and Behavior''. '''88''' (3): 358–65. doi:10.1016/j.pbb.2007.09.007. PMC 2322878. <nowiki>PMID 17905422</nowiki>.</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

==Subjective effects==

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 {{pharmacology}}
 {{Further|Serotonergic psychedelic}}
-DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>{{cite journal|last1=Fantegrossi|first1=W. E.|last2=Reissig|first2=C. J.|last3=Katz|first3=E. B.|last4=Yarosh|first4=H. L.|last5=Rice|first5=K. C.|last6=Winter|first6=J. C.|title=Hallucinogen-like effects of ''N'',''N''-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors in rodents|journal=Pharmacology Biochemistry and Behavior|volume=88|issue=3|pages=358-365|doi=10.1016/j.pbb.2007.09.007|pmid=17905422|pmc=2322878|issn=0091-3057|oclc=	848182005}}</ref>
+Studies on rodents have found that the effectiveness with which a selective 5-HT<sub>2A</sub> receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT<sub>2A</sub> receptor is an important site of action for DPT, but the modulatory actions of a 5-HT<sub>1A</sub> receptor antagonist also imply a 5-HT<sub>1A</sub>-mediated component to the actions of DPT.<ref>antegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC (January 2008). "Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents". ''Pharmacology, Biochemistry, and Behavior''. '''88''' (3): 358–65. doi:10.1016/j.pbb.2007.09.007. PMC 2322878. <nowiki>PMID 17905422</nowiki>.</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
-The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
 ==Subjective effects==