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Gabapentin: Difference between revisions
>Discount Pharmacologist Chemistry info, spelling error correction, and citations |
>Discount Pharmacologist Pharmacological information and citations added |
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Gabapentin transporter saturation occurs when large enough doses of gabapentin are consumed in a short enough period of time to result in the body being unable to absorb any more gabapentin, causing a significant reduction in bioavailability, which largely accounts for the drop in bioavailability seen with increasing doses. | Gabapentin transporter saturation occurs when large enough doses of gabapentin are consumed in a short enough period of time to result in the body being unable to absorb any more gabapentin, causing a significant reduction in bioavailability, which largely accounts for the drop in bioavailability seen with increasing doses. | ||
Gabapentin is a potent activator of voltage-gated potassium channels KCNQ3 and KCNQ5, even at low nanomolar concentrations. However, this activation is unlikely to be the dominant mechanism of gabapentin's therapeutic effects.<ref>Manville RW, Abbott GW (October 2018). "Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels". ''Mol Pharmacol''. '''94''' (4): 1155–1163. doi:10.1124/mol.118.112953. PMC 6108572. <nowiki>PMID 30021858</nowiki>.</ref> | |||
==Subjective effects== | ==Subjective effects== | ||