2C-B: Difference between revisions

'''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class.  

2C-B is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are closely related to the classical psychedelic [[mescaline]]. It is thought to produce its psychoactive effects by activating [[serotonin]] [[receptors]] in parts of the brain, although the precise mechanism is not fully understood.

2C-B was first discovered in 1974 by the American chemist [[Alexander Shulgin]], who documented its synthesis and subjective effects in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref>

In the 1970s, it was used in patients by a small number of psychotherapists in the United States and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref>  

It entered into recreational use shortly afterwards and was manufactured and sold commercially under names such as "Eros" and "Nexus" in head/smart shops and adult video stores before becoming federally prohibited by the DEA in 1995.<ref name="DEA2001">{{cite web|title=2C-B (Nexus) Reappears on the Club Drug Scene|url=http://www.justice.gov/archive/ndic/pubs0/665/665p.pdf|work=Information Bulletin|date=May 2001|publisher=Drug Enforcement Agency (DEA)|id=2001-L0424-002}}</ref>

[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports typically describe the effects of 2C-B as moderate, warm, and highly sensual. It is usually described as having a less serious or grandiose headspace than [[LSD]] or [[psilocybin mushrooms]], with a greater emphasis on visual and tactile effects. Smaller doses can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses produce a distinct classical psychedelic effect.  

2C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics (known to have low toxicity). However, more research is needed to fully understand the toxicity and health risks of 2C-B. It is highly advised to use [[harm reduction practices]] if using this substance.