Promethazine: Difference between revisions

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'''Promethazine''' (commonly sold as '''Phenergan''' and popularly known as one of the two active ingredients in "lean") is a first-generation [[psychoactive class::antihistamine]] of the [[chemical class::phenothiazine]] chemical class that produces [[muscle relaxation|muscle relaxing]], [[nausea suppression|nausea relieving]] and strong [[sedation|sedative]] effects when [[administered]]. It also reduces motion sickness and has anticholinergic properties.

'''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan,''' and popularly known as one of the two active ingredients in "lean") is a first-generation [[psychoactive class::antihistamine]] of the [[chemical class::phenothiazine]] chemical class that produces [[muscle relaxation|muscle relaxing]], [[nausea suppression|nausea relieving]] and strong [[sedation|sedative]] effects when [[administered]]. It also reduces motion sickness and has anticholinergic properties.

Promethazine was developed in the mid-1940s when a team of scientists from Rhône-Poulenc laboratories was able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine.<ref>Li, Jie Jack (2006). Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use. United Kingdom: Oxford University Press. p. 146. ISBN 9780199885282. Retrieved July 9, 2016.</ref> It was previously used as an antipsychotic,<ref>https://web.archive.org/web/20110718172715/http://www.cja-jca.org/cgi/reprint/6/4/375.pdf. Archived from the original (PDF) on July 18, 2011. Retrieved October 30, 2008</ref> although it is generally not administered for this purpose now. It has approximately 1/10 of the antipsychotic strength of chlorpromazine.

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 {{Talk:SubstanceBox/Promethazine}}
-'''Promethazine''' (commonly sold as '''Phenergan''' and popularly known as one of the two active ingredients in "lean") is a first-generation [[psychoactive class::antihistamine]] of the [[chemical class::phenothiazine]] chemical class that produces [[muscle relaxation|muscle relaxing]], [[nausea suppression|nausea relieving]] and strong [[sedation|sedative]] effects when [[administered]]. It also reduces motion sickness and has anticholinergic properties.
+'''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan,''' and popularly known as one of the two active ingredients in "lean") is a first-generation [[psychoactive class::antihistamine]] of the [[chemical class::phenothiazine]] chemical class that produces [[muscle relaxation|muscle relaxing]], [[nausea suppression|nausea relieving]] and strong [[sedation|sedative]] effects when [[administered]]. It also reduces motion sickness and has anticholinergic properties.
 Promethazine was developed in the mid-1940s when a team of scientists from Rhône-Poulenc laboratories was able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine.<ref>Li, Jie Jack (2006). Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use. United Kingdom: Oxford University Press. p. 146. ISBN 9780199885282. Retrieved July 9, 2016.</ref> It was previously used as an antipsychotic,<ref>https://web.archive.org/web/20110718172715/http://www.cja-jca.org/cgi/reprint/6/4/375.pdf. Archived from the original (PDF) on July 18, 2011. Retrieved October 30, 2008</ref> although it is generally not administered for this purpose now. It has approximately 1/10 of the antipsychotic strength of chlorpromazine.