Ayahuasca: Difference between revisions

>David Hedlund
===Potential antidepressant effects=== PMID: 29903051, https://clinicaltrials.gov/ct2/show/NCT02914769
>Tracer
Grammatics. MAOI is not a chemical class
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{{SubstanceBox/Ayahuasca}}
{{SubstanceBox/Ayahuasca}}
{{SummarySheet}}
{{SummarySheet}}
'''Ayahuasca''' (pronounced /eye-uh-WAHS-kuh/ and also known as '''Yagé''') is an umbrella term that refers to a wide variety of traditional and modern brews and infusions of natural plant sources that produce powerful psychoactive or [[hallucinogenic]] effects. Of these, it most commonly consists of a [[DMT]]-containing plant source in combination with one that contains an [[Chemical class::MAOI]] or [[RIMA]] (typically sources like [[Harmala_alkaloids#Banisteriopsis_caapi|B. caapi vine]] or [[Harmala_alkaloids#Peganum_harmala_.28Syrian_Rue.29|syrian rue]]) to produce uniquely potent, sometimes medicinal, [[psychoactive class::psychedelic]] effects.  
'''Ayahuasca''' (pronounced /eye-uh-WAHS-kuh/ and also known as '''Yagé''') is an umbrella term that refers to a wide variety of traditional and modern brews and infusions of natural plant sources that produce powerful psychoactive or [[hallucinogenic]] effects. Of these, it most commonly consists of a [[DMT]]-containing plant source in combination with one that contains an [[MAOI]] or [[RIMA]] (typically sources like [[Harmala_alkaloids#Banisteriopsis_caapi|B. caapi vine]] or [[Harmala_alkaloids#Peganum_harmala_.28Syrian_Rue.29|syrian rue]]) to produce uniquely potent, sometimes medicinal, [[psychoactive class::psychedelic]] effects.  


The co-consumption of an MAOI agent is necessary for the combination to work, as the DMT molecule (which is a [[monoamine]] closely related to [[serotonin]]) is rendered almost entirely inactive when digested by itself due to the presence of  [[monoamine]] oxidase enzymes in the stomach, which rapidly degrades it.<ref>http://www.sciencedirect.com/science/article/pii/S0040402006012373</ref>
The co-consumption of an MAOI agent is necessary for the combination to work, as the DMT molecule (which is a [[monoamine]] closely related to [[serotonin]]) is rendered almost entirely inactive when digested by itself due to the presence of  [[monoamine]] oxidase enzymes in the stomach, which rapidly degrades it.<ref>http://www.sciencedirect.com/science/article/pii/S0040402006012373</ref>