Talk:Antidepressant: Difference between revisions

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These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops. Serotonin releasing agents are not prescribed for depression.

===Norepinephrine reuptake inhibitors (NRIs)===

:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as ~~Trintellix~~. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref> Norepinephrine reuptake inhibitors can treat the tiredness commonly experienced with depression.

:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Edronax. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref> Norepinephrine reuptake inhibitors can treat the tiredness commonly experienced with depression.

===Norepinephrine-dopamine reuptake inhibitors (NDRIs)===

:NDRIs are believed to increase the level of extracellular [[norepinephrine]] and [[dopamine]], therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness.

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 These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops. Serotonin releasing agents are not prescribed for depression.
 ===Norepinephrine reuptake inhibitors (NRIs)===
-:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref> Norepinephrine reuptake inhibitors can treat the tiredness commonly experienced with depression.
+:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Edronax. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref> Norepinephrine reuptake inhibitors can treat the tiredness commonly experienced with depression.
 ===Norepinephrine-dopamine reuptake inhibitors (NDRIs)===
 :NDRIs are believed to increase the level of extracellular [[norepinephrine]] and [[dopamine]], therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness.