Thienodiazepines: Difference between revisions

Line 5:

Similar to [[benzodiazepines]], [[Thienodiazepine#Discontinuation|the sudden discontinuation of thienodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>

== List of substituted thienodiazepines==

==List of substituted thienodiazepines==

{| class="wikitable"

|-

Line 11:

! scope="col" style="width: 50px;" | '''R1'''

! scope="col" style="width: 50px;" | '''R2'''

! scope="col" style="width: 50px;" | '''R3'''

! scope="col" style="width: 50px;" | '''R5'''

! scope="col" style="width: 50px;" | '''R7'''

! scope="col" | '''Structure'''

|-

| [[~~Etizolam~~]] || C(CH3)=N- || =N-|| ~~C6~~H4Cl || CH2CH3 || [[File:~~Etizolam~~.svg|170px]]

| [[Brotizolam]] || C(CH3)=N- || =N-|| H2 || C6H4Cl || Br || [[File:Brotizolam.svg|170px]]

|-

| [[Deschloroetizolam]] || C(CH3)=N- || =N-|| C6H5 || CH2CH3 || [[File:Deschloroetizolam.svg|170px]]

| [[Deschloroetizolam]] || C(CH3)=N- || =N-|| H2 || C6H5 || CH2CH3 || [[File:Deschloroetizolam.svg|170px]]

|-

| [[Metizolam]] || CH=N- || =N-|| C6H4Cl || CH2CH3 || [[File:Metizolam.svg|170px]]

| [[Etizolam]] || C(CH3)=N- || =N-|| H2 || C6H4Cl || CH2CH3 || [[File:Etizolam.svg|170px]]

|-

| [[Fluclotizolam]] || C(CH3)=N- || =N-|| H2 || C6H4F || Cl || [[File:Fluclotizolam.svg|170px]]

|-

| [[Metizolam]] || CH=N- || =N-|| H2 || C6H4Cl || CH2CH3 || [[File:Metizolam.svg|170px]]

|-

|}

@@ Line 5: / Line 5: @@
 Similar to [[benzodiazepines]], [[Thienodiazepine#Discontinuation|the sudden discontinuation of thienodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>
-== List of substituted thienodiazepines==
+==List of substituted thienodiazepines==
 {| class="wikitable"
 |-
@@ Line 11: / Line 11: @@
 ! scope="col" style="width: 50px;" | '''R<sub>1</sub>'''
 ! scope="col" style="width: 50px;" | '''R<sub>2</sub>'''
+! scope="col" style="width: 50px;" | '''R<sub>3</sub>'''
 ! scope="col" style="width: 50px;" | '''R<sub>5</sub>'''
 ! scope="col" style="width: 50px;" | '''R<sub>7</sub>'''
 ! scope="col" | '''Structure'''
 |-
-| [[Etizolam]] || C(CH<sub>3</sub>)=N- || =N-|| C<sub>6</sub>H<sub>4</sub>Cl || CH<sub>2</sub>CH<sub>3</sub> || [[File:Etizolam.svg|170px]]
+| [[Brotizolam]] || C(CH<sub>3</sub>)=N- || =N-|| H<sub>2</sub> || C<sub>6</sub>H<sub>4</sub>Cl || Br || [[File:Brotizolam.svg|170px]]
 |-
-| [[Deschloroetizolam]] || C(CH<sub>3</sub>)=N- || =N-|| C<sub>6</sub>H<sub>5</sub> || CH<sub>2</sub>CH<sub>3</sub> || [[File:Deschloroetizolam.svg|170px]]
+| [[Deschloroetizolam]] || C(CH<sub>3</sub>)=N- || =N-|| H<sub>2</sub> || C<sub>6</sub>H<sub>5</sub> || CH<sub>2</sub>CH<sub>3</sub> || [[File:Deschloroetizolam.svg|170px]]
 |-
-| [[Metizolam]] || CH=N- || =N-|| C<sub>6</sub>H<sub>4</sub>Cl || CH<sub>2</sub>CH<sub>3</sub> || [[File:Metizolam.svg|170px]]
+| [[Etizolam]] || C(CH<sub>3</sub>)=N- || =N-|| H<sub>2</sub> || C<sub>6</sub>H<sub>4</sub>Cl || CH<sub>2</sub>CH<sub>3</sub> || [[File:Etizolam.svg|170px]]
+|-
+| [[Fluclotizolam]] || C(CH<sub>3</sub>)=N- || =N-|| H<sub>2</sub> || C<sub>6</sub>H<sub>4</sub>F || Cl || [[File:Fluclotizolam.svg|170px]]
+|-
+| [[Metizolam]] || CH=N- || =N-|| H<sub>2</sub> || C<sub>6</sub>H<sub>4</sub>Cl || CH<sub>2</sub>CH<sub>3</sub> || [[File:Metizolam.svg|170px]]
 |-
 |}