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Selective serotonin reuptake inhibitor: Difference between revisions
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SSRIs are capable of inconsistently inducing changes in visual perception - often during the beginning of treatment. | SSRIs are capable of inconsistently inducing changes in visual perception - often during the beginning of treatment. | ||
Most effects often disappear after a few weeks of treatment but may reappear or become more prominent when | Most effects often disappear after a few weeks of treatment but may reappear or become more prominent when combined with [[cannabis]] or [[amphetamines]]. | ||
====Enhancements==== | ====Enhancements==== | ||
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===Experience reports=== | ===Experience reports=== | ||
Experience reports can be found here: | Experience reports can be found here: | ||
* [https://erowid.org/experiences/subs/exp_SSRIs.shtml Erowid Experience Vaults: SSRIs] | |||
*[https://erowid.org/experiences/subs/exp_SSRIs.shtml Erowid Experience Vaults: SSRIs] | |||
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===Combinations=== | ===Combinations=== | ||
*'''[[Psychedelics]]''' - Due do the downregulation of 5-HT<sub>2A</sub> receptors caused by SSRIs, psychedelics can have a reduced effect. SSRIs can also reduce the chance of having a [[bad trip]] due to its [[Anxiety suppression|anxiolytic]] effects. | *'''[[Psychedelics]]''' - Due do the downregulation of 5-HT<sub>2A</sub> receptors caused by SSRIs, psychedelics can have a reduced effect. SSRIs can also reduce the chance of having a [[bad trip]] due to its [[Anxiety suppression|anxiolytic]] effects. | ||
*'''[[Cannabis]]''' - While on SSRIs, the [[anxiety]] and [[paranoia]] experienced on cannabis may be less intense, or not experienced at all. | *'''[[Cannabis]]''' - While on SSRIs, the [[anxiety]] and [[paranoia]] experienced on cannabis may be less intense, or not experienced at all. | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
*'''[[Dextromethorphan]]''' - Dextromethorphan is a serotonin releaser as well as an SSRI, therefore has a potential to cause [[serotonin syndrome]], a potentially deadly condition caused by extremely high serotonin levels. Although serotonin syndrome caused by this combination is uncommon, it is strongly advised not to combine them, especially if either is at a high dose. | *'''[[Dextromethorphan]]''' - Dextromethorphan is a serotonin releaser as well as an SSRI, therefore has a potential to cause [[serotonin syndrome]], a potentially deadly condition caused by extremely high serotonin levels. Although serotonin syndrome caused by this combination is uncommon, it is strongly advised not to combine them, especially if either is at a high dose. | ||
*'''[[Empathogens]]''' - Combining SSRIs with serotonergic empathogens such as [[MDMA]], [[mephedrone]], and AMT can result in [[serotonin syndrome]]. | *'''[[Empathogens]]''' - Combining SSRIs with serotonergic empathogens such as [[MDMA]], [[mephedrone]], and AMT can result in [[serotonin syndrome]]. | ||
*'''[[Tramadol]]''' - Combining SSRIs with tramadol can result in [[serotonin syndrome]]. | *'''[[Tramadol]]''' - Combining SSRIs with tramadol can result in [[serotonin syndrome]]. | ||
*'''Other antidepressants''' - Combining SSRIs with other antidepressants such as tricyclic antidepressants and [[MAOI|MAOIs]] can result in [[serotonin syndrome]]. Non serotonergic antidepressants such as [[bupropion]] are not dangerous to combine with SSRIs. | *'''Other antidepressants''' - Combining SSRIs with other antidepressants such as tricyclic antidepressants and [[MAOI|MAOIs]] can result in [[serotonin syndrome]]. Non serotonergic antidepressants such as [[bupropion]] are not dangerous to combine with SSRIs. | ||
==See also== | ==See also== | ||
*[[Psychoactive substance]] | *[[Psychoactive substance]] | ||
*[[Antidepressant]] | *[[Antidepressant]] | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor SSRI (Wikipedia)] | *[https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor SSRI (Wikipedia)] | ||
*[https://www.erowid.org/chemicals/ssris/ SSRIs (Erowid Vault)] | *[https://www.erowid.org/chemicals/ssris/ SSRIs (Erowid Vault)] | ||