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Talk:Loperamide: Difference between revisions
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'''Loperamide''', commonly branded as '''Imodium''', is a synthetic [[Psychoactive class::opioid]] of the [[Chemical class::phenylpiperidine]] chemical class that is sold as an anti-diarrheal agent. | '''Loperamide''', commonly branded as '''Imodium''', is a synthetic [[Psychoactive class::opioid]] of the [[Chemical class::phenylpiperidine]] chemical class that is sold as an anti-diarrheal agent. | ||
Loperamide crosses the blood-brain barrier in very small amounts, but traditionally these amounts have been considered insignificant. However, loperamide in high doses, has the potential for a significant analgesic or even [[euphoric]] effect.<ref>Poor Man's Methadone: A Case Report of Loperamide Toxicity. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/26355852</ref> Use of higher-than-recommended levels of loperamide has been associated with cardiotoxicity. Large doses taken at once can cause arrhythmia and cardiac arrest in some cases, raising serious questions about the safety of recreational loperamide.<ref name="Loperamide Toxicity">Clinical Review: Loperamide Toxicity. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/28506439</ref><ref>Ventricular Tachycardia Storm Induced by Loperamide Abuse. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/30967981</ref> | Loperamide crosses the blood-brain barrier in very small amounts, but traditionally these amounts have been considered insignificant. However, loperamide in high doses, has the potential for a significant [[analgesic]] or even [[euphoric]] effect.<ref>Poor Man's Methadone: A Case Report of Loperamide Toxicity. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/26355852</ref> Use of higher-than-recommended levels of loperamide has been associated with cardiotoxicity. Large doses taken at once can cause arrhythmia and cardiac arrest in some cases, raising serious questions about the safety of recreational loperamide.<ref name="Loperamide Toxicity">Clinical Review: Loperamide Toxicity. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/28506439</ref><ref>Ventricular Tachycardia Storm Induced by Loperamide Abuse. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/30967981</ref> | ||
==History and culture== | ==History and culture== | ||
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*[https://en.wikipedia.org/wiki/Loperamide Loperamide (Wikipedia)] | *[https://en.wikipedia.org/wiki/Loperamide Loperamide (Wikipedia)] | ||
*[https://www.erowid.org/pharms/loperamide/ Loperamide (Erowid Vault)] | *[https://www.erowid.org/pharms/loperamide/ Loperamide (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=8677 Loperamide ( | *[https://isomerdesign.com/PiHKAL/explore.php?id=8677 Loperamide (Isomer Design)] | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category:Opioid]] | [[Category:Opioid]] | ||
[[Category: | [[Category:Diphenylpropylamine]] | ||
[[Category:Phenylpiperidine]] | |||
[[Category:Approval]] | [[Category:Approval]] | ||
{{#set:Featured=true}} | {{#set:Featured=true}} | ||