PsychonautWiki Archive

Mirtazapine: Difference between revisions

← Older editNewer edit →
>Dextromethorphan
legality switzerland
>Unity
Rewrote introduction.
Line 1: Line 1:
{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/Mirtazapine}}
{{SubstanceBox/Mirtazapine}}
'''Mirtazapine''' (trade name '''Remeron''', among others) is an [[psychoactive class::antidepressant]] substance of the [[Chemical class::piperazinoazepine]] class. At high doses, it has been reported to act as an atypical [[Psychoactive class::psychedelic]] and [[psychoactive class::sedative]]. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).{{citation needed}}


'''Mirtazapine''' (trade name '''Remeron''', among others) is an [[psychoactive class::antidepressant]] substance of the [[Chemical class::piperazinoazepine]] class that produces atypical [[Psychoactive class::psychedelic]] and [[psychoactive class::sedative]] effects when [[administered]] at high doses.  
Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref> It is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> It has also been prescribed off-label for the treatment of
generalized anxiety disorder,<ref>A Review of the Pharmacological and Clinical Profile of Mirtazapine | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00198.x/abstract</ref><ref>Mirtazapine in Major Depression With Comorbid Generalized Anxiety Disorder | http://dx.doi.org/10.4088%2FJCP.v60n0705</ref> social anxiety disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Mirtazapine Treatment of Social Phobia in Women: A Randomized, Double-Blind, Placebo-Controlled Study | http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=2005&issue=12000&article=00015&type=abstract</ref> obsessive-compulsive disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Mirtazapine Treatment of Obsessive-Compulsive Disorder | http://journals.lww.com/psychopharmacology/Citation/2001/10000/Mirtazapine_Treatment_of_Obsessive_Compulsive.16.aspx</ref> panic disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Clinical Experience with Mirtazapine in the Treatment of Panic Disorder | http://www.crossref.org/iPage?doi=10.3109%2F10401239909147053</ref><ref>Mirtazapine in the Treatment of Panic Disorder | http://archpsyc.jamanetwork.com/article.aspx?articleid=1151071</ref> post-traumatic stress disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref> low appetite,<ref>http://www.ncbi.nlm.nih.gov/pubmed/12647431</ref><ref>Appetite stimulants in cystic fibrosis: a systematic review | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-277X.2007.00824.x/abstract</ref><ref>Management of symptons associated with advanced cancer: olanzapine and mirtazapine | http://informahealthcare.com/doi/abs/10.1586/14737140.2.4.365</ref> insomnia,<ref>http://www.ncbi.nlm.nih.gov/pubmed/9917581</ref><ref>Insomnia in Patients with Depression | http://link.springer.com/article/10.2165%2F00023210-200923040-00004</ref> nausea/vomiting,<ref>Tolerability and safety aspects of mirtazapine | http://onlinelibrary.wiley.com/doi/10.1002/hup.388/abstract</ref><ref>Mirtazapine Relieves Post-Electroconvulsive Therapy Headaches and Nausea: A Case Series and Review of the Literature | http://journals.lww.com/ectjournal/pages/articleviewer.aspx?year=2011&issue=06000&article=00016&type=abstract</ref><ref>Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2354.2006.00760.x/abstract</ref>
itching,<ref>Itch: scratching more than the surface | http://qjmed.oxfordjournals.org/content/96/1/7</ref><ref>Itch in systemic disease: therapeutic options | http://onlinelibrary.wiley.com/doi/10.1111/j.1529-8019.2005.00036.x/abstract</ref> and headaches and migraines.<ref>Mirtazapine Relieves Post-Electroconvulsive Therapy Headaches and Nausea: A Case Series and Review of the Literature | http://journals.lww.com/ectjournal/pages/articleviewer.aspx?year=2011&issue=06000&article=00016&type=abstract</ref><ref>Therapy of primary headaches: the role of antidepressants | http://link.springer.com/article/10.1007%2Fs10072-004-0280-x</ref><ref>[Effects of mirtazapine in patients with chronic tension-type headache. Literature review]. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17073214</ref>


Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
Higher doses of mirtazapine (that exceed the recommended prescription dose) are reported to produce an unusual mixture of [[psychedelic]] and [[sedative]] effects. [[Subjective effects]] include [[sedation]] and mild-moderate versions of [[geometry|open and closed-eye visuals]], [[conceptual thinking]], and [[euphoria]].


Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).{{citation needed}}
The toxicity and health risks of recreational mirtazapine use is not known. It is highly advised to use [[harm reduction practices]] if using this substance.  
 
Mirtazapine is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for the treatment of
generalized anxiety disorder,<ref>A Review of the Pharmacological and Clinical Profile of Mirtazapine | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00198.x/abstract</ref><ref>Mirtazapine in Major Depression With Comorbid Generalized Anxiety Disorder | http://dx.doi.org/10.4088%2FJCP.v60n0705</ref> social anxiety disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Mirtazapine Treatment of Social Phobia in Women: A Randomized, Double-Blind, Placebo-Controlled Study | http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=2005&issue=12000&article=00015&type=abstract</ref> obsessive-compulsive disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Mirtazapine Treatment of Obsessive-Compulsive Disorder | http://journals.lww.com/psychopharmacology/Citation/2001/10000/Mirtazapine_Treatment_of_Obsessive_Compulsive.16.aspx</ref> panic disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref><ref>Clinical Experience with Mirtazapine in the Treatment of Panic Disorder | http://www.crossref.org/iPage?doi=10.3109%2F10401239909147053</ref><ref>Mirtazapine in the Treatment of Panic Disorder | http://archpsyc.jamanetwork.com/article.aspx?articleid=1151071</ref> post-traumatic stress disorder,<ref>http://link.springer.com/article/10.2165%2F00023210-200923050-00006</ref> low appetite,<ref>http://www.ncbi.nlm.nih.gov/pubmed/12647431</ref><ref>Appetite stimulants in cystic fibrosis: a systematic review | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-277X.2007.00824.x/abstract</ref><ref>Management of symptons associated with advanced cancer: olanzapine and mirtazapine | http://informahealthcare.com/doi/abs/10.1586/14737140.2.4.365</ref> insomnia,<ref>http://www.ncbi.nlm.nih.gov/pubmed/9917581</ref><ref>Insomnia in Patients with Depression | http://link.springer.com/article/10.2165%2F00023210-200923040-00004</ref> nausea/vomiting,<ref>Tolerability and safety aspects of mirtazapine | http://onlinelibrary.wiley.com/doi/10.1002/hup.388/abstract</ref><ref>Mirtazapine Relieves Post-Electroconvulsive Therapy Headaches and Nausea: A Case Series and Review of the Literature | http://journals.lww.com/ectjournal/pages/articleviewer.aspx?year=2011&issue=06000&article=00016&type=abstract</ref><ref>Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2354.2006.00760.x/abstract</ref>
itching,<ref>Itch: scratching more than the surface | http://qjmed.oxfordjournals.org/content/96/1/7</ref><ref>Itch in systemic disease: therapeutic options | http://onlinelibrary.wiley.com/doi/10.1111/j.1529-8019.2005.00036.x/abstract</ref> and headaches and migraines.<ref>Mirtazapine Relieves Post-Electroconvulsive Therapy Headaches and Nausea: A Case Series and Review of the Literature | http://journals.lww.com/ectjournal/pages/articleviewer.aspx?year=2011&issue=06000&article=00016&type=abstract</ref><ref>Therapy of primary headaches: the role of antidepressants | http://link.springer.com/article/10.1007%2Fs10072-004-0280-x</ref><ref>[Effects of mirtazapine in patients with chronic tension-type headache. Literature review]. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17073214</ref>


==Chemistry==
==Chemistry==
Retrieved from "http://psy.st/wiki/Mirtazapine"