Opioids: Difference between revisions

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This negative change in endocrine function in males can lead to: reduced libido, erectile dysfunction, fatigue, depression, reduced facial and body hair, decreased muscle mass, and weight gain.

Another often observed long-term effect is hyperalgesia, an increase in the pain sensitivity of the person. This is specially seen in chronic pain patients on high dose opioid regimes. There is some evidence that NMDA antagonists like ketamine and opoids ~~with~~ that are also weak NMDA antagonist such as methadone, levorphanol and tramadol may help delay the onset of hyperalgesia or even revert it. (PubMed.gov / NCBI) | https://pubmed.ncbi.nlm.nih.gov/21412369</ref>

Another often observed long-term effect is hyperalgesia, an increase in the pain sensitivity of the person. This is specially seen in chronic pain patients on high dose opioid regimes. There is some evidence that NMDA antagonists like [[ketamine]] and opoids that are also weak NMDA antagonist such as [[methadone]], [[levorphanol]] and [[tramadol]] may help delay the onset of hyperalgesia or even revert it. (PubMed.gov / NCBI) | https://pubmed.ncbi.nlm.nih.gov/21412369</ref>

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this class of substances.

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 This negative change in endocrine function in males can lead to: reduced libido, erectile dysfunction, fatigue, depression, reduced facial and body hair, decreased muscle mass, and weight gain.
-Another often observed long-term effect is hyperalgesia, an increase in the pain sensitivity of the person. This is specially seen in chronic pain patients on high dose opioid regimes. There is some evidence that NMDA antagonists like ketamine and opoids with that are also weak NMDA antagonist such as methadone, levorphanol and tramadol may help delay the onset of hyperalgesia or even revert it. (PubMed.gov / NCBI) | https://pubmed.ncbi.nlm.nih.gov/21412369</ref>
+Another often observed long-term effect is hyperalgesia, an increase in the pain sensitivity of the person. This is specially seen in chronic pain patients on high dose opioid regimes. There is some evidence that NMDA antagonists like [[ketamine]] and opoids that are also weak NMDA antagonist such as [[methadone]], [[levorphanol]] and [[tramadol]] may help delay the onset of hyperalgesia or even revert it. (PubMed.gov / NCBI) | https://pubmed.ncbi.nlm.nih.gov/21412369</ref>
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this class of substances.