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Methaqualone: Difference between revisions
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Despite prior speculation, a 2015 study demonstrates that methaqualone exhibits distinct functional properties at the [[GABA]] [[receptor]] sites compared with other allosteric modulators, and it mediates these through a different mechanism than the [[barbiturates]] and [[benzodiazepines]] that it historically has been lumped together with.<ref name="ncbi qualuude study">A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26056160</ref> | Despite prior speculation, a 2015 study demonstrates that methaqualone exhibits distinct functional properties at the [[GABA]] [[receptor]] sites compared with other allosteric modulators, and it mediates these through a different mechanism than the [[barbiturates]] and [[benzodiazepines]] that it historically has been lumped together with.<ref name="ncbi qualuude study">A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26056160</ref> | ||
These distinctions could contribute to the reported differences in the in vivo effects induced by methaqualone and classic CNS [[depressants]]. In any case, the multifaceted functionality of methaqualone at [[GABA#Drugs_targeting_GABA-A|GABA A]] receptors seems to be at the root of its clinical efficacy, as well as the addiction liability and recreational use associated with the drug.<ref name="ncbi qualuude study" /> | These distinctions could contribute to the reported differences in the in vivo effects induced by methaqualone and classic CNS [[depressants]]. In any case, the multifaceted functionality of methaqualone at [[GABA#Drugs_targeting_GABA-A|GABA<sub>A</sub>]] receptors seems to be at the root of its clinical efficacy, as well as the addiction liability and recreational use associated with the drug.<ref name="ncbi qualuude study" /> | ||
It could be speculated that despite differences in targeted receptors, methaqualone essentially produces a variety of effects by binding to its receptor sites and magnifying the efficiency and effects of the [[neurotransmitter]] gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation would explain the resulting [[sedating]] or [[anxiety suppression|calming]] effects which ensue. | It could be speculated that despite differences in targeted receptors, methaqualone essentially produces a variety of effects by binding to its receptor sites and magnifying the efficiency and effects of the [[neurotransmitter]] gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation would explain the resulting [[sedating]] or [[anxiety suppression|calming]] effects which ensue. | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Substance]] | [[Category:Substance]] | ||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category:quinazolinone]] | |||
[[Category:Depressant]] | [[Category:Depressant]] | ||