Methoxetamine: Difference between revisions

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This substance was originally developed as a research chemical through the use of intelligent drug design.

MXE has almost no history of human usage prior and was first identified by the European Monitoring Centre for Drugs and Drug Addiction, which monitors the Internet for new psychoactive substances within the European Union, in November 2010. By July 2011, they had identified 58 websites selling the compound, at a cost of 145–195 euros for 10 grams.

==Chemistry==

MXE also acts as a [[dopamine]]-[[Reuptake Inhibitor|reuptake inhibitor]] and a [[serotonin]] [[reuptake inhibitor]] with [[Opioid receptors|µ-opioid]] affinity and typical [[Dissociatives#Subjective effects|dissociative]] effects. This provides an explanation for its euphoric and often stimulating effects.

The subjective physical effects of MXE however can be broken down into nine components all of which progressively intensify proportional to dosage. These are described below and generally include:

*'''[[Physical effects: Nausea|Nausea]]''' - It's worth noting that high dose MXE trips can sometimes result in nausea and vomiting at the peak of trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.

The general head space of MXE is often described as particularly euphoric and clear headed in comparison to that of [[DXM]] and [[Ketamine]]. The specific cognitive effects can be broken down into 8 separate subcomponents which are listed and described below:

*'''[[Cognitive effects: States of unity and interconnectedness|States of unity and interconnectedness]]'''

This substance does not enhance visual stimuli; instead it tends to degrade and decrease visual aptitude in a variety of ways which generally includes:

*'''[[Visual effects: Suppression of pattern recognition|Suppression of pattern recognition]]''' - This effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.

MXE exhibits a full array of dissociative distortions and alterations in visual perception which generally includes:

*'''[[Visual effects: Scenery slicing|Scenery slicing]]'''

The visual geometry found within MXE can be described as simplistic in complexity, slow in movement, large in size, immersive in presence and particularly dark in colour scheme when compared to that of [[DXM]] or [[Ketamine]].

At high dosages MXE can produce a full range of high level hallucinatory states in a fashion that that is less consistent and reproducible than that of many other commonly used psychedelic. These effects include:

*'''[[Visual effects: Internal hallucinations (dissociative)|Internal hallucinations]]''' - These hallucinatory states can be described as containing plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability and fixed in style. They can include both new experiences and memory replays which are capable of being weeks in length and real time in experience.

*'''[[Visual effects: External hallucinations (dissociative)|External hallucinations]]'''

The auditory effects of MXE are common in their occurrence and exhibit a range of effects which commonly includes:

*'''[[Auditory effects: Enhancements|Enhancements]]'''

*'''[[Auditory effects: Hallucinations|Hallucinations]]'''

The toxicity and long term health effects of recreational MXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MXE is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried MXE within the psychedelic community confirm that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses or using it sparingly (but nothing can be completely guaranteed).

In terms of MXE tolerance, this can take weeks to build up for some but for others it can take a single night of heavy use. Once a physical tolerance to MXE has set itself in, it can often take a month or more to reset itself.  

Reports of compulsive redosing during high dose trips resulting in over doses have also been reported. This can be prevented by keeping MXE far away from oneself when tripping and addiction can be avoided by manually limiting ones usage of the drug. It’s worth noting however that as with most [[hallucinogens]], most users note that the desire to use them can actually decrease with use.

In terms of its long term health effects, when used repeatedly and with excess for extended periods of time, MXE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because MXE is 4 times as potent as ketamine so significantly less of drug needs to be consumed. Symptoms of Ketamine cystitis can become extremely serious and can described as,

All of these however can easily be avoided by simply not using MXE on a daily or even weekly basis and manually limiting your usage of the substance.

*'''Germany:''' Possession, production and sale is illegal.

*'''Japan:''' Possession, production and sale is illegal.

*'''UK:''' MXE is a Class B drug.

*[[Dissociatives]]

*[[Arylcyclohexylamines]]

*[https://www.erowid.org/chemicals/methoxetamine/ MXE (Erowid)]

<references/>

[[Category:Arylcyclohexylamines]]