25I-NBOMe: Difference between revisions

25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I. It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. This change in structure results in a sixteen fold increase in potency when compared to 2C-I, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper which people often mistake for [[LSD]].

=Subjective effects=

==[[Physical effects - Psychedelics|Physical effects]]==

The physical effects of 25I-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

*'''[[Physical effects: Sublingual numbing|Sublingual numbing]]''' - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.

*'''[[Physical effects: Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.

*'''[[Physical effects: Decreased bodily weight|Decreased bodily weight]]''' - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.

*'''[[Physical effects: Stimulation|Stimulation]]''' - in terms of its effects on the physical energy levels of the tripper 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].

*'''[[Physical effects: Vasoconstriction|Vasoconstriction]]''' - this is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT_2A) modulates both vasoconstriction and vasodilation among its many other functions. It can be described as feelings of tightness within one's arms and legs.

*'''[[Physical effects: Nausea|Nausea]]''' - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be very considered very mild in its intensity.

==[[Cognitive effects - Psychedelics|Cognitive effects]]==

The head space of 25I-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.  

*'''[[Cognitive effects: Introspection|Introspection]]''' - this component is consistently manifested only in the context of a non-social setting in which the user is alone.

==[[Visual effects - Psychedelics|Visual effects]]==

===[[Visual effects - Psychedelics#Enhancements|Enhancements]]===

===[[Visual effects - Psychedelics#Distortions|Distortions]]===

===[[Visual effects - Psychedelics#Geometry|Geometry]]===

The visual geometry that is present throughout this trip is often described as similar in appearance to that of [[LSD]]. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within [[2C-I]] and most of the [[2C-x]] family in general as well as completely on par with [[LSD]], [[Psilocin]] and [[DMT]] at appropriately high dosages.  

In terms of their behaviour, 25I-NBOMe’s geometry leads onto [[Visual effects - Psychedelics#7A - Exposure to entirety of neurological structure|Level 7A]] visual geometry with [[Visual effects - Psychedelics#7B - Exposure to inner mechanics of human consciousness|Level 7B]] remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

===[[Visual effects - Psychedelics#Hallucinatory States|Hallucinatory states]]===

*'''[[Visual effects: External hallucinations (psychedelic)|External hallucinations]]'''

*'''[[Visual effects: Internal hallucinations (psychedelic)|Internal hallucinations]]''' - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

==[[Auditory effects - Psychedelics|Auditory effects]]==

= Toxicity and harm potential =

==Lethal Dosage==

25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The [[LD50]] has not yet been determined.<ref name="Fatalities / Deaths"> "Fatalities / Deaths". Erowid. April 26 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref> [[PsychonautWiki]] advises that due to 25I-NBOMe extreme potency it should not be insufflated as this method of administration appears to have led to several deaths in the past year.<ref>http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/</ref>

It came to media attention in early 2012 after a cluster of seven non-fatal [[overdose]]s with the drug were reported in or around Richmond, Virginia.<ref name="Kids overdosing on new drug"> "Kids overdosing on new drug. Laura Geller, WWBT NBC12, Feb 18, 2012 | http://www.nbc12.com/story/16964534/kids-overdosing-on-new-drug</ref><ref name="New street drug"> New street drug causing concern among medics. Vanessa Araiza, WBRC, Feb 28, 2012 | http://www.wsfa.com/story/16977573/new-street-drug-causing-concern-among-medics</ref> As of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.<ref name="NY Daily news"> New drug N-bomb hits the street, terrifying parents, troubling cops | http://www.nydailynews.com/news/national/new-synthetic-hallucinogen-n-bomb-killing-users-cops-article-1.1336327</ref> In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.<ref name="NY Daily news"> Breaking Bad: Digital Drug Sales, Analog Drug Deaths. Craig Malisow, Houston Press, March 13, 2013 | http://www.houstonpress.com/2013-03-14/news/motion-research-charles-carlton/</ref>

==Tolerance and addiction potential==

=Legal issues=

=See Also=

=References=