4-AcO-DMT: Difference between revisions

Line 29:

==Pharmacology==

Psilacetin ~~acts as a~~ [[Serotonin#~~The_5~~-~~HT_System~~|5-HT1A]]~~, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5 and 5-HT6~~ [[Agonist#Agonists|partial agonist]]. ~~The psychedelic effects are believed to come from psilacetins efficacy at~~ the ~~5-HT2A receptors. There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]]~~ and ~~all~~ [[~~Adrenaline#The_Adrenergic_System|adrenoreceptors~~]].

Psilacetin's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT System|5-HT2A receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

In the body, psilacetin is thought to be deacetylated to psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven however and is based on reports that most users can not tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.

@@ Line 29: / Line 29: @@
 ==Pharmacology==
-Psilacetin acts as a [[Serotonin#The_5-HT_System|5-HT<sub>1A</sub>]], 5-HT<sub>2A</sub>, 5-HT<sub>2B</sub>, 5-HT<sub>2C</sub>, 5-HT<sub>5</sub> and 5-HT<sub>6</sub> [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from psilacetins efficacy at the 5-HT<sub>2A</sub> receptors. There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]] and all [[Adrenaline#The_Adrenergic_System|adrenoreceptors]].
+Psilacetin's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT System|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
 In the body, psilacetin is thought to be deacetylated to psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven however and is based on reports that most users can not tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.