Lisdexamfetamine: Difference between revisions

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'''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''' and '''Vyvanse''') is a prescription [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. Lisdextroamphetamine is a [[prodrug]] for [[Amphetamine#Enantiomers|d-amphetamine]] (dexamphetamine, or dextroamphetamine) which is a strong central nervous system (CNS) stimulant.

'''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''' and '''Vyvanse''') is a prescription [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. Lisdextroamphetamine is a "mutual [[prodrug]]" ([https://en.wikipedia.org/wiki/Codrug codrug]) for [[Amphetamine#Enantiomers|d-amphetamine]] (dexamphetamine, or dextroamphetamine) which is a strong central nervous system (CNS) stimulant.

Lisdexamfetamine is approved for the treatment of attention deficit hyperactivity disorder (ADHD) and moderate to severe binge-eating disorder.<ref>https://www.drugs.com/pro/vyvanse.html</ref> This means that outside of the oral route, its effects are independent of [[route of administration]]. Other routes of administration like [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset.

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==Chemistry==

Lisdexamphetamine ~~consists of the dextro-rotary stereoisomer of~~ [~~[amphetamine~~]~~] bonded to~~ the ~~essential~~ amino acid L-~~Lysine~~. Amphetamine is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. It can be referred to as a methyl homologue of [[phenethylamine]] as it has the same general formula, differing only in the addition of one methyl group.

Lisdexamphetamine is a [https://en.wikipedia.org/wiki/Codrug codrug] composed of the amino acid L-lysine, covalently bonded to dextroamphetamine.<ref name="pmid17407369">{{cite journal | vauthors = Blick SK, Keating GM | title = Lisdexamfetamine | journal = Paediatric Drugs | volume = 9 | issue = 2 | pages = 129–135; discussion 136–138 | date = 2007 | pmid = 17407369 | doi = 10.2165/00148581-200709020-00007 | url = }}</ref> Amphetamine is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. It can be referred to as a methyl homologue of [[phenethylamine]] as it has the same general formula, differing only in the addition of one methyl group.

==Pharmacology==

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 {{SummarySheet}}
 {{SubstanceBox/Lisdexamfetamine}}
-'''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''' and '''Vyvanse''') is a prescription [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. Lisdextroamphetamine is a [[prodrug]] for [[Amphetamine#Enantiomers|<small>d</small>-amphetamine]] (dexamphetamine, or dextroamphetamine) which is a strong central nervous system (CNS) stimulant.
+'''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''' and '''Vyvanse''') is a prescription [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. Lisdextroamphetamine is a "mutual [[prodrug]]" ([https://en.wikipedia.org/wiki/Codrug codrug]) for [[Amphetamine#Enantiomers|<small>d</small>-amphetamine]] (dexamphetamine, or dextroamphetamine) which is a strong central nervous system (CNS) stimulant.
 Lisdexamfetamine is approved for the treatment of attention deficit hyperactivity disorder (ADHD) and moderate to severe binge-eating disorder.<ref>https://www.drugs.com/pro/vyvanse.html</ref> This means that outside of the oral route, its effects are independent of [[route of administration]]. Other routes of administration like [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset.
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 ==Chemistry==
-Lisdexamphetamine consists of the dextro-rotary stereoisomer of [[amphetamine]] bonded to the essential amino acid L-Lysine. Amphetamine is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub>. It can be referred to as a methyl homologue of [[phenethylamine]] as it has the same general formula, differing only in the addition of one methyl group.
+Lisdexamphetamine is a [https://en.wikipedia.org/wiki/Codrug codrug] composed of the amino acid <small>L</small>-lysine, covalently bonded to dextroamphetamine.<ref name="pmid17407369">{{cite journal | vauthors = Blick SK, Keating GM | title = Lisdexamfetamine | journal = Paediatric Drugs | volume = 9 | issue = 2 | pages = 129–135; discussion 136–138 | date = 2007 | pmid = 17407369 | doi = 10.2165/00148581-200709020-00007 | url = }}</ref> Amphetamine is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain with an additional methyl substitution at R<sub>α</sub>. It can be referred to as a methyl homologue of [[phenethylamine]] as it has the same general formula, differing only in the addition of one methyl group.
 ==Pharmacology==