F-Phenibut: Difference between revisions

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'''F-Phenibut''' (also known as '''Fluorophenibut''', and '''~~Fluorobut~~''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.

'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.

The substance can be classified as a [[GABApentinoid |gabapentinoid]], a class which contains other substances such as [[gabapentin]], [[pregabalin]] <ref>"Wyllie's Treatment of Epilepsy: Principles and Practice" | https://books.google.co.uk/books?id=j9t6Qg0kkuUC&pg=RA1-PA423&redir_esc=y#v=onepage&q&f=false</ref>, [https://en.wikipedia.org/wiki/Baclofen baclofen], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | https://doi.org/10.1111/j.1527-3458.2001.tb00211.x</ref><ref>"Practical Management of Pain. Elsevier Health Sciences" | https://books.google.co.uk/books?id=kfcDAQAAQBAJ&pg=PA1006&redir_esc=y#v=onepage&q&f=false</ref> It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one" />

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 {{SubstanceBox/F-Phenibut}}
-'''F-Phenibut''' (also known as '''Fluorophenibut''', and '''Fluorobut''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.
+'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.
 The substance can be classified as a [[GABApentinoid |gabapentinoid]], a class which contains other substances such as [[gabapentin]], [[pregabalin]] <ref>"Wyllie's Treatment of Epilepsy: Principles and Practice" | https://books.google.co.uk/books?id=j9t6Qg0kkuUC&pg=RA1-PA423&redir_esc=y#v=onepage&q&f=false</ref>, [https://en.wikipedia.org/wiki/Baclofen baclofen], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | https://doi.org/10.1111/j.1527-3458.2001.tb00211.x</ref><ref>"Practical Management of Pain. Elsevier Health Sciences" | https://books.google.co.uk/books?id=kfcDAQAAQBAJ&pg=PA1006&redir_esc=y#v=onepage&q&f=false</ref> It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one" />