Gabapentin: Difference between revisions

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'''Gabapentin''' (also known as '''Neurontin''') is a [[psychoactive class::depressant]] substance of the [[chemical class::gabapentinoid]] class which is used as an [[anticonvulsant]], [[analgesic]] and [[anxiolytic]]. It was originally developed to treat epilepsy and is currently used to relieve neuropathic pain and [[restless leg syndrome]].<ref>Restless legs syndrome: clinical presentation diagnosis and treatment | http://www.sleep-journal.com/article/S1389-9457(15)00647-4/abstract</ref> It is recommended as a first line agent for the treatment of neuropathic pain arising from diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.<ref>EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20402746</ref>

Gabapentin is ~~also an effective tool for treating~~ social anxiety disorder, panic disorder~~<ref>The role of anticonvulsant drugs in~~ anxiety ~~disorders: a critical review of the evidence (PubMed.gov / NCBI) | https://www~~.~~ncbi.nlm.nih.gov/pubmed/17502773</ref>~~<ref>Manual of Clinical Psychopharmacology | https://books.google.co.uk/books?id=D3zz1NCm3qcC&pg=PA345&hl=en</ref> ~~and generalized anxiety disorder.~~<ref>Successful Psychopharmacology: Evidence-Based Treatment Solutions for Achieving Remission | https://books.google.co.uk/books?id=dnAlO_Veu2QC&pg=PA124&hl=en</ref><ref>https://books.google.co.uk/books?id=82oiYYHGNTQC&pg=PA765&hl=en</ref> It ~~is these~~ effects ~~which~~ provide gabapentin with some recreational potential in a manner that can be accurately compared to a mild [[benzodiazepine]]. However, these recreational effects diminish very quickly with repeated usage and are most commonly reported by those who do not have a tolerance to this compound.

Gabapentin is used off-label to treat social anxiety disorder, panic disorder, and general anxiety disorder.<ref>Manual of Clinical Psychopharmacology | https://books.google.co.uk/books?id=D3zz1NCm3qcC&pg=PA345&hl=en</ref><ref>Successful Psychopharmacology: Evidence-Based Treatment Solutions for Achieving Remission | https://books.google.co.uk/books?id=dnAlO_Veu2QC&pg=PA124&hl=en</ref><ref>https://books.google.co.uk/books?id=82oiYYHGNTQC&pg=PA765&hl=en</ref> Its efficacy in the treatment of these disorders is unclear and the evidence is "somewhat mixed".<ref>[https://www.ncbi.nlm.nih.gov/pubmed/17502773] The role of anticonvulsants in anxiety disorders: a critical review of the evidence.</ref><ref>[https://www.jmcp.org/doi/abs/10.18553/jmcp.2002.8.4.266] Gabapentin Use in a Managed Medicaid Population</ref><ref>[https://annals.org/aim/fullarticle/727539/narrative-review-promotion-gabapentin-analysis-internal-industry-documents] Promotion of Gabapentin</ref>

It's analgesic and anxiolytic effects provide gabapentin with some recreational potential in a manner that can be accurately compared to a mild [[benzodiazepine]]. However, these recreational effects diminish very quickly with repeated usage and are most commonly reported by those who do not have a tolerance to this compound.

==Chemistry==

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 '''Gabapentin''' (also known as '''Neurontin''') is a [[psychoactive class::depressant]] substance of the [[chemical class::gabapentinoid]] class which is used as an [[anticonvulsant]], [[analgesic]] and [[anxiolytic]]. It was originally developed to treat epilepsy and is currently used to relieve neuropathic pain and [[restless leg syndrome]].<ref>Restless legs syndrome: clinical presentation diagnosis and treatment | http://www.sleep-journal.com/article/S1389-9457(15)00647-4/abstract</ref> It is recommended as a first line agent for the treatment of neuropathic pain arising from diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.<ref>EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20402746</ref>
-Gabapentin is also an effective tool for treating social anxiety disorder, panic disorder<ref>The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/17502773</ref><ref>Manual of Clinical Psychopharmacology | https://books.google.co.uk/books?id=D3zz1NCm3qcC&pg=PA345&hl=en</ref> and generalized anxiety disorder.<ref>Successful Psychopharmacology: Evidence-Based Treatment Solutions for Achieving Remission | https://books.google.co.uk/books?id=dnAlO_Veu2QC&pg=PA124&hl=en</ref><ref>https://books.google.co.uk/books?id=82oiYYHGNTQC&pg=PA765&hl=en</ref> It is these effects which provide gabapentin with some recreational potential in a manner that can be accurately compared to a mild [[benzodiazepine]]. However, these recreational effects diminish very quickly with repeated usage and are most commonly reported by those who do not have a tolerance to this compound.
+Gabapentin is used off-label to treat social anxiety disorder, panic disorder, and general anxiety disorder.<ref>Manual of Clinical Psychopharmacology | https://books.google.co.uk/books?id=D3zz1NCm3qcC&pg=PA345&hl=en</ref><ref>Successful Psychopharmacology: Evidence-Based Treatment Solutions for Achieving Remission | https://books.google.co.uk/books?id=dnAlO_Veu2QC&pg=PA124&hl=en</ref><ref>https://books.google.co.uk/books?id=82oiYYHGNTQC&pg=PA765&hl=en</ref> Its efficacy in the treatment of these disorders is unclear and the evidence is "somewhat mixed".<ref>[https://www.ncbi.nlm.nih.gov/pubmed/17502773] The role of anticonvulsants in anxiety disorders: a critical review of the evidence.</ref><ref>[https://www.jmcp.org/doi/abs/10.18553/jmcp.2002.8.4.266] Gabapentin Use in a Managed Medicaid Population</ref><ref>[https://annals.org/aim/fullarticle/727539/narrative-review-promotion-gabapentin-analysis-internal-industry-documents] Promotion of Gabapentin</ref>
+It's analgesic and anxiolytic effects provide gabapentin with some recreational potential in a manner that can be accurately compared to a mild [[benzodiazepine]]. However, these recreational effects diminish very quickly with repeated usage and are most commonly reported by those who do not have a tolerance to this compound.
 ==Chemistry==