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Talk:Substituted pyrrolidinophenones: Difference between revisions
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[[File:Α-PPP.svg|thumb|right|301px||Generic structure of pyrrolidinophenone molecule.]] | [[File:Α-PPP.svg|thumb|right|301px||Generic structure of pyrrolidinophenone molecule.]] | ||
'''Substituted pyrrolidinophenones''' are a chemical class of psychoactive compounds... | '''Substituted pyrrolidinophenones''' are a chemical class of psychoactive compounds that are based on the structure of [[alpha-pyrrolidinopropiophenone]] (α-PPP). Pyrrolidinophenones have [[stimulant]] effects and are presumed to be more potent and addictive than others stimulants of class [[Substituted amphetamine|amphetamine]] and [[cathinone]].<ref name="Bath salts">Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV) | https://www.sciencedirect.com/science/article/pii/S002839081400080X</ref> | ||
==Chemistry== | ==Chemistry== | ||
Pyrrolidinophenones are a chemical class releated to [[cathinones]], and they differs from other cathinones in that they contains a [[pyrrolidine]] ring in amino group. | |||
==Pharmacology== | ==Pharmacology== | ||
Presence of a [[pyrrolidine]] ring in any [[cathinone]]-like compound confers potent uptake blocking properties at DAT and NET. Thus, pyrrolidinophenones are mechanistically distinct from ring-substituted cathinones, such as [[mephedrone]] and [[methylone]], which act as non-selective substrates for monoamine transporters and trigger transmitter release. Importantly, [[MDPV]] and [[α-PVP]] are similar in potency and transporter selectivity, indicating that the presence of the 3,4-methylenedioxy substituent in MDPV does not exert much influence on the profile of transporter activity. By contrast, alkyl chain length extending from the α-carbon is a critical structural feature, with shorter chain length (i.e., [[α-PPP]], methyl) yielding less potent transporter-blocking properties when compared to longer chain length (i.e., [[α-PVP]], propyl).<ref name="Bath salts"/> | |||
==List of substituted pyrrolidinophenones == | ==List of substituted pyrrolidinophenones == | ||