4-AcO-DMT: Difference between revisions

Line 29:

=Pharmacology=

Psilacetin acts as a 5-HT2A, 5-HT2C and 5-HT1A [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from ~~psilacetin~~'s efficacy at the 5-HT2A receptors. ~~At high doses, there~~ is ~~some~~ efficacy ~~to noradrenaline~~ receptors.

Psilacetin acts as a [[Serotonin#The_5-HT_System|5-HT1A]], 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5 and 5-HT6 [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from LSD's efficacy at the 5-HT2A receptors. There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]] and all [[Adrenaline#The_Adrenergic_System|adrenoreceptors]].

In the body, psilacetin is thought to be deacetylated to psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven however and is based on reports that most users can not tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.

@@ Line 29: / Line 29: @@
 =Pharmacology=
-Psilacetin acts as a 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from psilacetin's efficacy at the 5-HT<sub>2A</sub> receptors. At high doses, there is some efficacy to noradrenaline receptors.
+Psilacetin acts as a [[Serotonin#The_5-HT_System|5-HT<sub>1A</sub>]], 5-HT<sub>2A</sub>, 5-HT<sub>2B</sub>, 5-HT<sub>2C</sub>, 5-HT<sub>5</sub> and 5-HT<sub>6</sub> [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from LSD's efficacy at the 5-HT<sub>2A</sub> receptors. There is also efficacy at all [[Dopamine#The Dopamine System|dopamine receptors]] and all [[Adrenaline#The_Adrenergic_System|adrenoreceptors]].
 In the body, psilacetin is thought to be deacetylated to psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven however and is based on reports that most users can not tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.