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Pregabalin: Difference between revisions
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*'''[[Effect::Spontaneous bodily sensations]]''' - The general "body high" of pregabalin can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | *'''[[Effect::Spontaneous bodily sensations]]''' - The general "body high" of pregabalin can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | ||
*'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss. | *'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss. | ||
*'''[[Effect::Tactile enhancement]]''' | |||
*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.{{citation needed}} | *'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.{{citation needed}} | ||
*'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref> Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/</ref> | *'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref> Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/</ref> | ||
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*'''[[Effect::Perception of bodily lightness]]''' - At very high doses, some users report feeling lighter. | *'''[[Effect::Perception of bodily lightness]]''' - At very high doses, some users report feeling lighter. | ||
*'''[[Effect::Increased libido]]''' ''or'' '''[[Effect::Decreased libido]]''' | *'''[[Effect::Increased libido]]''' ''or'' '''[[Effect::Decreased libido]]''' | ||
*'''[[Effect::Orgasm suppression]]''' | |||
*'''[[Effect::Motor control loss]]''' | *'''[[Effect::Motor control loss]]''' | ||
*'''[[Effect::Seizure suppression]]'''<ref> Pregabalin | http://www.epilepsy.com/medications/pregabalin </ref><ref> Pregabalin for the management of partial epilepsy | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646650/</ref> | *'''[[Effect::Seizure suppression]]'''<ref> Pregabalin | http://www.epilepsy.com/medications/pregabalin </ref><ref> Pregabalin for the management of partial epilepsy | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646650/</ref> | ||
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*'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | *'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | ||
*'''[[Effect::Anxiety suppression]]''' | *'''[[Effect::Anxiety suppression]]''' | ||
*'''[[Effect::Emotion enhancement]]''' | |||
*'''[[Effect::Cognitive euphoria]]'''<ref> Abuse and Misuse Potential of Pregabalin: A Review of the Clinical Evidence. (2012, April 12). Retrieved December 26, 2016, from Canadian Agency for Drugs and Technologies in Health, http://www.dpic.org/sites/default/files/PregabalinAbuse_CADTH_24Apr2012.pdf</ref> - Many users who take pregabalin describe a moderate to even intense euphoria, even at lower doses. Many users describe it as similar to [[opioid]] induced euphoria. The sensation itself can be described as powerful and overwhelming feelings of emotional bliss, contentment, and happiness. | *'''[[Effect::Cognitive euphoria]]'''<ref> Abuse and Misuse Potential of Pregabalin: A Review of the Clinical Evidence. (2012, April 12). Retrieved December 26, 2016, from Canadian Agency for Drugs and Technologies in Health, http://www.dpic.org/sites/default/files/PregabalinAbuse_CADTH_24Apr2012.pdf</ref> - Many users who take pregabalin describe a moderate to even intense euphoria, even at lower doses. Many users describe it as similar to [[opioid]] induced euphoria. The sensation itself can be described as powerful and overwhelming feelings of emotional bliss, contentment, and happiness. | ||
*'''[[Effect::Disinhibition]]''' | *'''[[Effect::Disinhibition]]''' | ||
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*'''[[Effect::Increased music appreciation]]''' | *'''[[Effect::Increased music appreciation]]''' | ||
*'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | *'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | ||
*'''[[Effect::Immersion enhancement]]''' | |||
*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At very high doses, pregabalin can induce a mild dissociative state. | *'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At very high doses, pregabalin can induce a mild dissociative state. | ||
*'''[[Effect::Suicidal ideation]]''' | *'''[[Effect::Suicidal ideation]]''' | ||