6-APB: Difference between revisions

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'''6-(2-Aminopropyl)benzofuran''' (also known as '''6-APB''' and '''"Benzofury"''') is a novel [[psychoactive class::entactogen]] substance of the [[chemical class::benzofuran]] class. It is structurally related to entactogens like [[MDA]], [[MDMA]], [[5-APB]], and [[5-MAPB]].

~~'''6-(2-Aminopropyl)benzofuran''' (also known as '''~~6-APB~~''' and '''"Benzofury"''') is a novel~~ [[~~psychoactive class::entactogen~~]] ~~substance of the~~ [[~~chemical class::benzofuran~~]] ~~class~~. ~~Its characteristic effects include [[anxiety suppression]]~~, ~~[[disinhibition]]~~, ~~[[muscle relaxation]]~~, and ~~[[euphoria]]~~. ~~It is structurally related to entactogens like [[MDA]]~~, ~~[[MDMA]]~~, ~~[[5~~-~~APB]]~~, and ~~[[5-MAPB]]~~.

6-APB was first synthesized in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]].<ref name="Nichols">Monte, A. P., Marona-Lewicka, D., Cozzi, N. V., & Nichols, D. E. (1993). Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogs of 3, 4-(methylenedioxy) amphetamine. Journal of Medicinal Chemistry, 36(23), 3700-3706. https://doi.org/10.1021/jm00075a027</ref> However, it did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market. It was sold along with other novel benzofuran entactogens under the name "Benzofury" before its sale and import were subsequently banned.{{citation needed}}

~~6-APB was first synthesized in 1993 by~~ [[~~David E. Nichols~~]] ~~as a potential non-neurotoxic alternative to~~ [[~~MDMA~~]]~~.<ref name="Nichols">Monte~~, ~~A. P.~~, ~~Marona-Lewicka~~, D.~~, Cozzi, N. V., & Nichols, D. E. (1993). Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogs of 3, 4~~-~~(methylenedioxy) amphetamine. Journal~~ of Medicinal Chemistry, 36(23), 3700-3706. https://doi.org/10.1021/jm00075a027</ref> However, it did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and ~~global research chemicals market. It was sold along with~~ other ~~novel benzofuran~~ entactogens ~~under the name "Benzofury" before its sale and import were subsequently banned~~.~~{{citation needed}}~~

[[Subjective effects]] include [[anxiety suppression]], [[disinhibition]], [[muscle relaxation]], and [[euphoria]]. 6-APB's effects are commonly compared to those of [[MDA]] and other entactogens.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 6-APB, and it has only a brief history of human usage. It has been marketed alongside [[research chemical]] [[entactogens]] like [[5-MAPB]] and [[5-APB]] as a legal, grey-market alternative to [[MDMA]], and is typically commercially distributed by online [[research chemical]] vendors. It is highly advised to use [[harm reduction practices]] if using this substance.

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 {{SummarySheet}}
 {{SubstanceBox/6-APB}}
+'''6-(2-Aminopropyl)benzofuran''' (also known as '''6-APB''' and '''"Benzofury"''') is a novel [[psychoactive class::entactogen]] substance of the [[chemical class::benzofuran]] class. It is structurally related to entactogens like [[MDA]], [[MDMA]], [[5-APB]], and [[5-MAPB]].
-'''6-(2-Aminopropyl)benzofuran''' (also known as '''6-APB''' and '''"Benzofury"''') is a novel [[psychoactive class::entactogen]] substance of the [[chemical class::benzofuran]] class. Its characteristic effects include [[anxiety suppression]], [[disinhibition]], [[muscle relaxation]], and [[euphoria]]. It is structurally related to entactogens like [[MDA]], [[MDMA]], [[5-APB]], and [[5-MAPB]].
+-APB was first synthesized in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]].<ref name="Nichols">Monte, A. P., Marona-Lewicka, D., Cozzi, N. V., & Nichols, D. E. (1993). Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogs of 3, 4-(methylenedioxy) amphetamine. Journal of Medicinal Chemistry, 36(23), 3700-3706. https://doi.org/10.1021/jm00075a027</ref> However, it did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market. It was sold along with other novel benzofuran entactogens under the name "Benzofury" before its sale and import were subsequently banned.{{citation needed}}
--APB was first synthesized in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]].<ref name="Nichols">Monte, A. P., Marona-Lewicka, D., Cozzi, N. V., & Nichols, D. E. (1993). Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogs of 3, 4-(methylenedioxy) amphetamine. Journal of Medicinal Chemistry, 36(23), 3700-3706. https://doi.org/10.1021/jm00075a027</ref> However, it did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market. It was sold along with other novel benzofuran entactogens under the name "Benzofury" before its sale and import were subsequently banned.{{citation needed}}
+[[Subjective effects]] include [[anxiety suppression]], [[disinhibition]], [[muscle relaxation]], and [[euphoria]]. 6-APB's effects are commonly compared to those of [[MDA]] and other entactogens.
 Very little data exists about the pharmacological properties, metabolism, and toxicity of 6-APB, and it has only a brief history of human usage. It has been marketed alongside [[research chemical]] [[entactogens]] like [[5-MAPB]] and [[5-APB]] as a legal, grey-market alternative to [[MDMA]], and is typically commercially distributed by online [[research chemical]] vendors. It is highly advised to use [[harm reduction practices]] if using this substance.