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Talk:Loperamide: Difference between revisions
>Corticosteroid m yo great job on this article :D |
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Concurrent administration of P-glycoprotein inhibitors such as quinidine potentially allows loperamide to cross the blood–brain barrier and produce central [[morphine]]-like effects. Loperamide taken with quinidine was found to produce respiratory depression, indicative of central [[opioid]] action.<ref>Increased drug delivery to the brain by P-glycoprotein inhibition. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11014404</ref> | Concurrent administration of P-glycoprotein inhibitors such as quinidine potentially allows loperamide to cross the blood–brain barrier and produce central [[morphine]]-like effects. Loperamide taken with quinidine was found to produce respiratory depression, indicative of central [[opioid]] action.<ref>Increased drug delivery to the brain by P-glycoprotein inhibition. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11014404</ref> | ||
Loperamide is metabolized by the cytochrome P450 (CYP) system and is a substrate for the CYP3A4 isoenzyme. Concurrent administration with CYP3A4 inhibitors may elevate loperamide concentrations.<ref>Loperamide: a pharmacological review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/18192961</ref> | Loperamide is metabolized by the cytochrome P450 (CYP) system and is a substrate for the CYP3A4 isoenzyme. Concurrent administration with [[Template:List CYP450 inhibitors|CYP3A4 inhibitors]] may elevate loperamide concentrations.<ref>Loperamide: a pharmacological review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/18192961</ref> | ||
==Subjective effects== | ==Subjective effects== | ||