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SAM-e: Difference between revisions
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{toxicity}} | {{toxicity}} | ||
There are no clinically significant side-effects of acute SAM-e supplementation. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAM-e. While not common, it appears to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref> S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref> Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref> | There are no clinically significant side-effects of acute SAM-e supplementation. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAM-e. While not common, it appears to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref>S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref>Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref> | ||
SAM-e is also hypothesized to raise homocystine to harmful levels, but this has yet to be proven in a laboratory environment. <ref>Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. | http://www.ncbi.nlm.nih.gov/pubmed/9262350</ref> Still, it is advised to take Sam-e along with folate and B12. | SAM-e is also hypothesized to raise homocystine to harmful levels, but this has yet to be proven in a laboratory environment. <ref>Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. | http://www.ncbi.nlm.nih.gov/pubmed/9262350</ref> Still, it is advised to take Sam-e along with folate and B12. | ||
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==Legal status== | ==Legal status== | ||
*'''United States''' - SAM-e is approved and legal over the counter for purchase. | *'''United States''' - SAM-e is approved and legal over the counter for purchase. | ||
*'''Germany''' - SAM-e is sold as a dietary supplement. | |||
*'''Russia''' - SAM-e is available by prescription. | *'''Russia''' - SAM-e is available by prescription. | ||
*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref> | *'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref> | ||