GHB: Difference between revisions

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Although there have been reported fatalities due to GHB withdrawal, reports are inconclusive and further research is needed.<ref>Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence | http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.1997.tb03640.x/abstract</ref>

Tolerance will develop to the sedative-hypnotic effects [[Time to full tolerance::within several weeks of continuous use]]. After cessation, the tolerance returns to baseline in [[Time to zero tolerance::7 - 14 days]]. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction.

Tolerance will develop to the sedative-hypnotic effects [[Time to full tolerance::within several weeks of continuous use]]. After cessation, the tolerance returns to baseline in [[Time to zero tolerance::7 - 14 days]]. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. GHB presents cross-tolerance with [[1,4-Butanediol]] and [[GBL]], since these act as [[Prodrug|prodrugs]] for GHB. Cross-tolerance with [[alcohol]] and [[baclofen]] has been shown in rats.<ref>https://www.sciencedirect.com/science/article/pii/0014299994006873</ref><ref>https://www.sciencedirect.com/science/article/pii/S0014299906009964</ref>

===Dangerous interactions===

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 Although there have been reported fatalities due to GHB withdrawal, reports are inconclusive and further research is needed.<ref>Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence | http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.1997.tb03640.x/abstract</ref>
-Tolerance will develop to the sedative-hypnotic effects [[Time to full tolerance::within several weeks of continuous use]]. After cessation, the tolerance returns to baseline in [[Time to zero tolerance::7 - 14 days]]. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction.
+Tolerance will develop to the sedative-hypnotic effects [[Time to full tolerance::within several weeks of continuous use]]. After cessation, the tolerance returns to baseline in [[Time to zero tolerance::7 - 14 days]]. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. GHB presents cross-tolerance with [[1,4-Butanediol]] and [[GBL]], since these act as [[Prodrug|prodrugs]] for GHB. Cross-tolerance with [[alcohol]] and [[baclofen]] has been shown in rats.<ref>https://www.sciencedirect.com/science/article/pii/0014299994006873</ref><ref>https://www.sciencedirect.com/science/article/pii/S0014299906009964</ref>
 ===Dangerous interactions===