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Alprazolam: Difference between revisions
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{toxicity}} | |||
[[File:harmchart.png|thumb|right|300px|Radar plot showing relative physical harm, social harm, and dependence of benzodiazepines in comparison to other drugs.<ref>Development of a rational scale to assess the harm of drugs of potential misuse (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0140673607604644</ref>]] | [[File:harmchart.png|thumb|right|300px|Radar plot showing relative physical harm, social harm, and dependence of benzodiazepines in comparison to other drugs.<ref>Development of a rational scale to assess the harm of drugs of potential misuse (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0140673607604644</ref>]] | ||
Alprazolam has a [[Toxicity::low toxicity]] relative to dose.<ref>Benzodiazepine metabolism: an analytical perspective (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/18855614</ref> However, it is [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[opioids]]]]. | Alprazolam has a [[Toxicity::low toxicity]] relative to dose.<ref>Benzodiazepine metabolism: an analytical perspective (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/18855614</ref> However, it is [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[opioids]]]]. | ||
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The acute oral [[LD50|LD<sub>50</sub>]] in rats is 331–2171 mg/kg. Other experiments in animals have indicated that cardiopulmonary collapse can occur following massive intravenous doses of alprazolam. | The acute oral [[LD50|LD<sub>50</sub>]] in rats is 331–2171 mg/kg. Other experiments in animals have indicated that cardiopulmonary collapse can occur following massive intravenous doses of alprazolam. | ||
=== | ===Dependence and abuse potential=== | ||
Alprazolam is [[Addiction potential::extremely physically and psychologically addictive]]. | Alprazolam is [[Addiction potential::extremely physically and psychologically addictive]]. | ||
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Alprazolam presents cross-tolerance with [[Cross-tolerance::all [[benzodiazepines]]]], meaning that after its consumption all benzodiazepines will have a reduced effect. | Alprazolam presents cross-tolerance with [[Cross-tolerance::all [[benzodiazepines]]]], meaning that after its consumption all benzodiazepines will have a reduced effect. | ||
===Overdose=== | |||
{{BenzoOD}} | |||
===Discontinuation=== | ===Discontinuation=== | ||
{{BenzoDiscontinuation}} | {{BenzoDiscontinuation}} | ||
===Dangerous interactions=== | ===Dangerous interactions=== | ||