Talk:Baclofen: Difference between revisions

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'''Baclofen''' (also known as '''Lioresal''', '''Gablofen''', '''Kemstro''', '''Liofen''', '''Баклосан''') is a [[psychoactive class::depressant]] substance of the [[chemical class::gabapentinoid]] class. It is a derivative of [[GABA]] and is chemically related to [[phenibut]], [[pregabalin]], and [[gabapentin]]. It primarily acts as a [[GABA]]<sub>B</sub> [[receptor]] [[agonist]].

~~'''~~Baclofen~~''' (also known as '''Lioresal'''~~, ~~'''Gablofen'''~~, ~~'''Kemstro'''~~, ~~'''Liofen''', '''Баклосан'''~~) ~~is a [[psychoactive class~~:~~:depressant]] substance of the [[chemical class::gabapentinoid]] class~~.

Baclofen was synthesized in 1962 at Ciba-Geigy, a Swiss pharmaceutical company.<ref>Froestl, Wolfgang (2010). "Chemistry and Pharmacology of GABAb Receptor Ligands". In Blackburn, Thomas P. (ed.). GABAb Receptor Pharmacology – A Tribute to Norman Bowery. Advances in Pharmacology. 58. pp. 19–62. doi:10.1016/S1054-3589(10)58002-5. ISBN 978-0-12-378647-0. PMID 20655477.</ref> Today, it is used clinically to treat muscle spasticity, and holds promise as a treatment for [[alcoholism]].<ref>Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/23869179</ref>

~~Baclofen is a [[GABA]]<sub>B~~</~~sub~~> ~~[[receptor]] [[agonist]] and central nervous system [[depressant]]~~ used to treat spasticity, and holds promise as a treatment for [[alcoholism]]<ref>Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/23869179</ref>.

~~The drug is sometimes taken in non-medical settings because it can provide anxiety reduction, sedation, and some euphoria. It’s usually described as somewhat similar to [[phenibut]] in its effects.~~

~~It is chemically related to~~ [[~~phenibut~~]], [[~~pregabalin~~]], and [[~~gabapentin~~]].

[[Subjective effects]] include [[sedation]], [[anxiety suppression]], [[muscle relaxation]], and moderate [[euphoria]]. It is usually described as somewhat similar to [[phenibut]] in its effects.

It is highly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

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==Legal status==

*'''Russia:''' Baclofen is available through a prescription.

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 {{SummarySheet}}
 {{SubstanceBox/Baclofen}}
+'''Baclofen''' (also known as '''Lioresal''', '''Gablofen''', '''Kemstro''', '''Liofen''', '''Баклосан''') is a [[psychoactive class::depressant]] substance of the [[chemical class::gabapentinoid]] class. It is a derivative of [[GABA]] and is chemically related to [[phenibut]], [[pregabalin]], and [[gabapentin]]. It primarily acts as a [[GABA]]<sub>B</sub> [[receptor]] [[agonist]].
-'''Baclofen''' (also known as '''Lioresal''', '''Gablofen''', '''Kemstro''', '''Liofen''', '''Баклосан''') is a [[psychoactive class::depressant]] substance of the [[chemical class::gabapentinoid]] class.
+Baclofen was synthesized in 1962 at Ciba-Geigy, a Swiss pharmaceutical company.<ref>Froestl, Wolfgang (2010). "Chemistry and Pharmacology of GABAb Receptor Ligands". In Blackburn, Thomas P. (ed.). GABAb Receptor Pharmacology – A Tribute to Norman Bowery. Advances in Pharmacology. 58. pp. 19–62. doi:10.1016/S1054-3589(10)58002-5. ISBN 978-0-12-378647-0. PMID 20655477.</ref> Today, it is used clinically to treat muscle spasticity, and holds promise as a treatment for [[alcoholism]].<ref>Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/23869179</ref>
-Baclofen is a [[GABA]]<sub>B</sub> [[receptor]] [[agonist]] and central nervous system [[depressant]] used to treat spasticity, and holds promise as a treatment for [[alcoholism]]<ref>Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/23869179</ref>.
-The drug is sometimes taken in non-medical settings because it can provide anxiety reduction, sedation, and some euphoria. It’s usually described as somewhat similar to [[phenibut]] in its effects.
-It is chemically related to [[phenibut]], [[pregabalin]], and [[gabapentin]].
+[[Subjective effects]] include [[sedation]], [[anxiety suppression]], [[muscle relaxation]], and moderate [[euphoria]]. It is usually described as somewhat similar to [[phenibut]] in its effects.
+It is highly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==
@@ Line 97: / Line 98: @@
 ==Legal status==
+{{legalStub}}
 *'''Russia:''' Baclofen is available through a prescription.