Template:DangerousInteractions/Amphetamines: Difference between revisions

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*'''[[UncertainInteraction::Alcohol|[[Alcohol]]]]''' - Drinking on stimulants is risky because the sedative effects of the alcohol ~~are reduced, and these are what~~ the body uses to gauge drunkenness. This ~~typically~~ leads to excessive drinking with greatly reduced inhibitions, ~~high~~ risk of liver damage and increased dehydration. ~~They~~ will also allow ~~you~~ to drink past a point where ~~you~~ might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the ~~Alcohol~~ and the stimulant less. ~~Extended release formulations may severely impede sleep, further worsening~~ the ~~hangover~~.

*'''[[UncertainInteraction::Alcohol|[[Alcohol]]]]''' - Drinking on stimulants is considered risky because it reduces the sedative effects of the alcohol that the body uses to gauge drunkenness. This often leads to excessive drinking with greatly reduced inhibitions, increasing the risk of liver damage and increased dehydration. The effects of stimulants will also allow one to drink past a point where they might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less.

*'''[[UncertainInteraction::GHB|[[GHB]]]]'''/'''[[UncertainInteraction::GBL|[[GBL]]]]''' - Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the ~~patient~~ and cause respiratory arrest.

*'''[[UncertainInteraction::Cannabis|[[Cannabis]]]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] and [[paranoia]] which can lead to negative experiences.

*'''[[UncertainInteraction::Cannabis|[[Cannabis]]]]''' - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences.

*'''[[UncertainInteraction::GHB|[[GHB]]]]'''/'''[[UncertainInteraction::GBL|[[GBL]]]]''' - Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the user and cause respiratory arrest.

*'''[[UncertainInteraction::Opioids|[[Opioids]]]]''' - Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.

*'''[[UncertainInteraction::Cocaine|[[Cocaine]]]]''' - This combination of stimulants will increase strain on the heart. It is not favored as cocaine has a mild blocking effect on dopamine releasers like amphetamine.

*'''[[UncertainInteraction::Caffeine|[[Caffeine]]]]''' - This combination of stimulants is generally considered unnecessary and may increase strain on the heart, as well as potentially causing anxiety and physical discomfort.

*'''[[DangerousInteraction::Tramadol|[[Tramadol]]]]''' - Tramadol and stimulants both increase the risk of seizures.

*'''[[UnsafeInteraction::DXM|[[DXM]]]]''' - Both substances raise heart rate, in extreme cases, panic attacks caused by these ~~drugs~~ have led to more serious heart issues.

*'''[[UnsafeInteraction::DXM|[[DXM]]]]''' - Both substances raise heart rate, in extreme cases, panic attacks caused by these substances have led to more serious heart issues.

*'''[[UncertainInteraction::Ketamine|[[Ketamine]]]]''' - No unexpected interactions~~, though likely~~ to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

*'''[[UncertainInteraction::Ketamine|[[Ketamine]]]]''' - No unexpected interactions. Likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

*'''[[UnsafeInteraction::PCP|[[PCP]]]]''' - ~~This combination can easily lead to hypermanic~~ states.

*'''[[UnsafeInteraction::PCP|[[PCP]]]]''' - Increased risk of tachycardia, hypertension, and manic states.

*'''[[UncertainInteraction::Methoxetamine|[[Methoxetamine]]]]''' - ~~Risk~~ of tachycardia, hypertension, and manic states.

*'''[[UncertainInteraction::Methoxetamine|[[Methoxetamine]]]]''' - Increased risk of tachycardia, hypertension, and manic states.

*'''[[UncertainInteraction::Cocaine|[[Cocaine]]]]''' - This combination of stimulants will increase strain on the heart. It is not favored as cocaine has a mild blocking effect on dopamine releasers like amphetamine.

*'''[[UncertainInteraction::Psychedelics|[[Psychedelics]]]]''' ('''''[[UncertainInteraction::Psilocybin mushrooms|[[Psilocybin mushrooms]]]]''''', '''''[[UncertainInteraction::Mescaline|[[mescaline]]]]''''', '''''[[UncertainInteraction::LSD|[[LSD]]]]''''', '''''[[UncertainInteraction::DMT|[[DMT]]]]''''', '''''[[UncertainInteraction::2C-x|[[2C-x]]]]''''', '''''[[UnsafeInteraction::DOx|[[DOx]]]]''''', '''''[[UnsafeInteraction::2C-T-x|[[2C-T-x]]]]''''', '''''[[UnsafeInteraction::5-MeO-xxT]]''''') - The increased anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of [[anxiety]], [[paranoia]], and [[thought loops]].

*'''[[UncertainInteraction::Caffeine|[[Caffeine]]]]''' - This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.

**'''[[UnsafeInteraction::25x-NBOMe|[[25x-NBOMe]]]]''' - Amphetamines and NBOMes both provide considerable stimulation that when combined they can result in tachycardia, hypertension, vasoconstriction and, in extreme cases, heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.

*'''[[UncertainInteraction::Psychedelics|[[Psychedelics]]]]''' ('''''[[UncertainInteraction::Psilocybin mushrooms|[[Psilocybin mushrooms]]]]''''', '''''[[UncertainInteraction::Mescaline|[[mescaline]]]]''''', '''''[[UncertainInteraction::LSD|[[LSD]]]]''''', '''''[[UncertainInteraction::DMT|[[DMT]]]]''''', '''''[[UncertainInteraction::2C-x|[[2C-x]]]]''''', '''''[[UnsafeInteraction::DOx|[[DOx]]]]''''', '''''[[UnsafeInteraction::2C-T-x|[[2C-T-x]]]]''''', '''''[[UnsafeInteraction::5-MeO-xxT]]''''') - The ~~focus and~~ anxiety ~~enhancements~~ caused by stimulants is magnified by psychedelics and results in an increased risk of [[anxiety]], [[paranoia]], and [[thought loops]].

**'''[[UnsafeInteraction::25x-NBOMe|[[25x-NBOMe]]]]''' - Amphetamines and NBOMes both provide considerable stimulation~~. When~~ combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.

*'''[[DangerousInteraction::aMT|[[aMT]]]]'''

*'''[[DangerousInteraction::MAOIs|[[MAOIs]]]]''' - MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.

@@ Line 1: / Line 1: @@
-*'''[[UncertainInteraction::Alcohol|[[Alcohol]]]]''' - Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the Alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
+*'''[[UncertainInteraction::Alcohol|[[Alcohol]]]]''' - Drinking on stimulants is considered risky because it reduces the sedative effects of the alcohol that the body uses to gauge drunkenness. This often leads to excessive drinking with greatly reduced inhibitions, increasing the risk of liver damage and increased dehydration. The effects of stimulants will also allow one to drink past a point where they might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less.
-*'''[[UncertainInteraction::GHB|[[GHB]]]]'''/'''[[UncertainInteraction::GBL|[[GBL]]]]''' - Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
+*'''[[UncertainInteraction::Cannabis|[[Cannabis]]]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] and [[paranoia]] which can lead to negative experiences.
-*'''[[UncertainInteraction::Cannabis|[[Cannabis]]]]''' - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences.
+*'''[[UncertainInteraction::GHB|[[GHB]]]]'''/'''[[UncertainInteraction::GBL|[[GBL]]]]''' - Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the user and cause respiratory arrest.
 *'''[[UncertainInteraction::Opioids|[[Opioids]]]]''' - Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
+*'''[[UncertainInteraction::Cocaine|[[Cocaine]]]]''' - This combination of stimulants will increase strain on the heart. It is not favored as cocaine has a mild blocking effect on dopamine releasers like amphetamine.
+*'''[[UncertainInteraction::Caffeine|[[Caffeine]]]]''' - This combination of stimulants is generally considered unnecessary and may increase strain on the heart, as well as potentially causing anxiety and physical discomfort.
 *'''[[DangerousInteraction::Tramadol|[[Tramadol]]]]''' - Tramadol and stimulants both increase the risk of seizures.
-*'''[[UnsafeInteraction::DXM|[[DXM]]]]''' - Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
+*'''[[UnsafeInteraction::DXM|[[DXM]]]]''' - Both substances raise heart rate, in extreme cases, panic attacks caused by these substances have led to more serious heart issues.
-*'''[[UncertainInteraction::Ketamine|[[Ketamine]]]]''' - No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
+*'''[[UncertainInteraction::Ketamine|[[Ketamine]]]]''' - No unexpected interactions. Likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
-*'''[[UnsafeInteraction::PCP|[[PCP]]]]''' - This combination can easily lead to hypermanic states.
+*'''[[UnsafeInteraction::PCP|[[PCP]]]]''' - Increased risk of tachycardia, hypertension, and manic states.
-*'''[[UncertainInteraction::Methoxetamine|[[Methoxetamine]]]]''' - Risk of tachycardia, hypertension, and manic states.
+*'''[[UncertainInteraction::Methoxetamine|[[Methoxetamine]]]]''' - Increased risk of tachycardia, hypertension, and manic states.
-*'''[[UncertainInteraction::Cocaine|[[Cocaine]]]]''' - This combination of stimulants will increase strain on the heart. It is not favored as cocaine has a mild blocking effect on dopamine releasers like amphetamine.
+*'''[[UncertainInteraction::Psychedelics|[[Psychedelics]]]]''' ('''''[[UncertainInteraction::Psilocybin mushrooms|[[Psilocybin mushrooms]]]]''''', '''''[[UncertainInteraction::Mescaline|[[mescaline]]]]''''', '''''[[UncertainInteraction::LSD|[[LSD]]]]''''', '''''[[UncertainInteraction::DMT|[[DMT]]]]''''', '''''[[UncertainInteraction::2C-x|[[2C-x]]]]''''', '''''[[UnsafeInteraction::DOx|[[DOx]]]]''''', '''''[[UnsafeInteraction::2C-T-x|[[2C-T-x]]]]''''', '''''[[UnsafeInteraction::5-MeO-xxT]]''''') - The increased anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of [[anxiety]], [[paranoia]], and [[thought loops]].
-*'''[[UncertainInteraction::Caffeine|[[Caffeine]]]]''' - This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
+**'''[[UnsafeInteraction::25x-NBOMe|[[25x-NBOMe]]]]''' - Amphetamines and NBOMes both provide considerable stimulation that when combined they can result in tachycardia, hypertension, vasoconstriction and, in extreme cases, heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
-*'''[[UncertainInteraction::Psychedelics|[[Psychedelics]]]]''' ('''''[[UncertainInteraction::Psilocybin mushrooms|[[Psilocybin mushrooms]]]]''''', '''''[[UncertainInteraction::Mescaline|[[mescaline]]]]''''', '''''[[UncertainInteraction::LSD|[[LSD]]]]''''', '''''[[UncertainInteraction::DMT|[[DMT]]]]''''', '''''[[UncertainInteraction::2C-x|[[2C-x]]]]''''', '''''[[UnsafeInteraction::DOx|[[DOx]]]]''''', '''''[[UnsafeInteraction::2C-T-x|[[2C-T-x]]]]''''', '''''[[UnsafeInteraction::5-MeO-xxT]]''''') - The focus and anxiety enhancements caused by stimulants is magnified by psychedelics and results in an increased risk of [[anxiety]], [[paranoia]], and [[thought loops]].
-**'''[[UnsafeInteraction::25x-NBOMe|[[25x-NBOMe]]]]''' - Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
 *'''[[DangerousInteraction::aMT|[[aMT]]]]'''
 *'''[[DangerousInteraction::MAOIs|[[MAOIs]]]]''' - MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.