2C-T-2: Difference between revisions

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{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
The mechanism of action that produces 2C-T-2’s [[hallucinogenic]] and [[entheogen]]ic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. This mechanism of action is shared by many other psychedelic [[phenethylamine]]s and [[tryptamine]]s.  
The mechanism of action that produces 2C-T-2’s [[hallucinogenic]] and [[entheogen]]ic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. This mechanism of action is shared by many other psychedelic [[phenethylamine]]s and [[tryptamine]]s.  
{| class="wikitable"
|-
! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
|-
| 5-HT<sub>1D</sub>  || 85.9
|-
| 5-HT<sub>2A</sub> || 39.9
|-
| 5-HT<sub>2B</sub> || 6
|-
| 5-HT<sub>2C</sub>  || 53.9
|-
| α<sub>2C</sub>  || 166
|}


Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]].{{citation needed}} Furthermore, many compounds of the amphetamine-analogs of the [[2C-T-x]] have been found to have highly selective MAO-A inhibition<ref>https://www.ncbi.nlm.nih.gov/pubmed/15801832</ref><ref>http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.689.281&rep=rep1&type=pdf</ref>. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>
Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]].{{citation needed}} Furthermore, many compounds of the amphetamine-analogs of the [[2C-T-x]] have been found to have highly selective MAO-A inhibition<ref>https://www.ncbi.nlm.nih.gov/pubmed/15801832</ref><ref>http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.689.281&rep=rep1&type=pdf</ref>. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>
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