Salvinorin A: Difference between revisions

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Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT2A receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. The unique structure of salvinorin A lacks features commonly associated with opioid ligand binding such as a guaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.

Salvinorin A also acts as a potent agonist at [[dopamine|D2]] receptors,<ref>https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.

Salvinorin A also acts as a potent agonist at [[dopamine|D2]] receptors,<ref name="d2">https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.

{| class="wikitable"

|-

! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>

|-

| KOR || 4.3

|-

| D2 || 5-10<ref name="d2">https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref>

|}

==Subjective effects==

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 Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT<sub>2A</sub> receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. The unique structure of salvinorin A lacks features commonly associated with opioid ligand binding such as a guaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.
-Salvinorin A also acts as a potent agonist at [[dopamine|D<sub>2</sub>]] receptors,<ref>https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.
+Salvinorin A also acts as a potent agonist at [[dopamine|D<sub>2</sub>]] receptors,<ref name="d2">https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.
+{| class="wikitable"
+|-
+! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
+|-
+| KOR  || 4.3
+|-
+| D<sub>2</sub>  || 5-10<ref name="d2">https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref>
+|}
 ==Subjective effects==