DPT: Difference between revisions

Line 19:

DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT2A]] and [[Serotonin#The 5-HT system|5-HT1A]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>

{| class="wikitable"

|-

! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>

|-

| 5-HT1A || 31.8

|-

| 5-HT1B || 854

|-

| 5-HT1D || 619

|-

| 5-HT2A || 2579

|-

| 5-HT2B || 42

|-

| 5-HT2C || 1567

|-

| 5-HT7 || 284

|-

| α1B || 443

|-

| α2A || 457.6

|-

| α2B || 42

|-

| SERT || 157

|-

| I1 || 340

|-

| σ1 || 397

|-

| H1 || 125.1

|}

The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

@@ Line 19: / Line 19: @@
 {{Further|Serotonergic psychedelic}}
 DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
+{| class="wikitable"
+|-
+! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
+|-
+| 5-HT<sub>1A</sub>  || 31.8
+|-
+| 5-HT<sub>1B</sub>  || 854
+|-
+| 5-HT<sub>1D</sub>  || 619
+|-
+| 5-HT<sub>2A</sub> || 2579
+|-
+| 5-HT<sub>2B</sub> || 42
+|-
+| 5-HT<sub>2C</sub>  || 1567
+|-
+| 5-HT<sub>7</sub>  || 284
+|-
+| α<sub>1B</sub>  || 443
+|-
+| α<sub>2A</sub>  || 457.6
+|-
+| α<sub>2B</sub>  || 42
+|-
+| SERT  || 157
+|-
+| I<sub>1</sub>  || 340
+|-
+| σ<sub>1</sub>  || 397
+|-
+| H<sub>1</sub>  || 125.1
+|}
 The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.