2C-T-2: Difference between revisions

Line 27:

The mechanism of action that produces 2C-T-2’s [[hallucinogenic]] and [[entheogen]]ic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the [[Serotonin#The 5-HT system|5-HT2A receptor]] as a [[Agonist#Agonists|partial agonist]]. This mechanism of action is shared by many other psychedelic [[phenethylamine]]s and [[tryptamine]]s.

Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]]. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>

{| class="wikitable"

|-

! Site !! Binding Affinity (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>

|-

| 5-HT1D || 85.9

|-

| 5-HT2A || 39.9

|-

| 5-HT2B || 6

|-

| 5-HT2C || 53.9

|-

| α2C || 166

|}

Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]]. Furthermore, many compounds of the amphetamine-analogs of the [[2C-T-x]] have been found to have highly selective MAO-A inhibition<ref>https://www.ncbi.nlm.nih.gov/pubmed/15801832</ref><ref>http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.689.281&rep=rep1&type=pdf</ref>. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

@@ Line 27: / Line 27: @@
 The mechanism of action that produces 2C-T-2’s [[hallucinogenic]] and [[entheogen]]ic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. This mechanism of action is shared by many other psychedelic [[phenethylamine]]s and [[tryptamine]]s.
-Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]]. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>
+{| class="wikitable"
+|-
+! Site !! Binding Affinity (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref>
+|-
+| 5-HT<sub>1D</sub>  || 85.9
+|-
+| 5-HT<sub>2A</sub> || 39.9
+|-
+| 5-HT<sub>2B</sub> || 6
+|-
+| 5-HT<sub>2C</sub>  || 53.9
+|-
+| α<sub>2C</sub>  || 166
+|}
+Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of [[2C-T-7]]) are known to act as selective [[MAOI|monoamine oxidase A inhibitors]]. Furthermore, many compounds of the amphetamine-analogs of the [[2C-T-x]] have been found to have highly selective MAO-A inhibition<ref>https://www.ncbi.nlm.nih.gov/pubmed/15801832</ref><ref>http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.689.281&rep=rep1&type=pdf</ref>. Therefore, this substance may likewise have [[MAOI]] effects.<ref>http://www.sciencedirect.com/science/article/pii/S0006295206005971</ref>
 However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.