Selective serotonin reuptake inhibitor: Difference between revisions

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*'''[[Effect::Depression]]'''

*'''[[Effect::Anxiety]]'''

*'''[[Effect::Mindfulness supression]]'''

*'''[[Effect::Irritability]]'''

*'''[[Effect::Motivation suppression]]'''

*'''[[Effect::Suicidal ideation]]''' <ref>Björkenstam, C., Möller, J., Gunilla Ringbäck, G., Salmi, P., Hallgvist, J., & Ljung, R. (2013, September 9). An Association between Initiation of Selective Serotonin Reuptake Inhibitors and Suicide - A Nationwide Register-Based Case-Crossover Study. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767591/</ref> - Upon first introduction, some users (especially people under the age of 25)<ref>https://www.mayoclinic.org/diseases-conditions/teen-depression/in-depth/antidepressants/art-20047502</ref> can experience increase suicidal and self harming thoughts and behaviors. This effect usually subsides within 6-8 weeks.

*'''[[Effect::Insomnia]]'''

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==Examples==

===Citalopram===

Citalopram is an SSRI sold under the brand name '''Celexa''' in the United States. Citalopram is indicated for the treatment of a major depressive disorder. Citalopram was approved in 1998 by the Food and Drug Administration for the treatment of major depressive disorder.<ref>Nemeroff, CB (2012). Management of Treatment-Resistant Major Psychiatric Disorders. USA: Oxford University Press. p. 30.</ref> Citalopram is almost exclusively found as the hydrobromide salt, which is the only form approved by the FDA.<ref> Citalopram | https://www.drugs.com/citalopram.html</ref>

Citalopram is an SSRI sold under the brand name '''Celexa''' in the United States. Citalopram is indicated for the treatment of a major depressive disorder. Citalopram was approved in 1998 by the Food and Drug Administration for the treatment of major depressive disorder.<ref>Nemeroff, CB (2012). Management of Treatment-Resistant Major Psychiatric Disorders. USA: Oxford University Press. p. 30.</ref> Citalopram is almost exclusively found as the hydrobromide salt, which is the only form approved by the FDA.<ref>Citalopram | https://www.drugs.com/citalopram.html</ref>

===Escitalopram===

Escitalopram is an SSRI sold under the brand name '''Lexapro''' in the United States. Escitalopram is indicated for the treatment of major depressive disorder and anxiety disorders. It is the s-enantiomer of citalopram, and both have similar efficacy. Escitalopram was FDA approved in 2002.<ref> Escitalopram | https://www.drugs.com/cdi/escitalopram.html</ref>

Escitalopram is an SSRI sold under the brand name '''Lexapro''' in the United States. Escitalopram is indicated for the treatment of major depressive disorder and anxiety disorders. It is the s-enantiomer of citalopram, and both have similar efficacy. Escitalopram was FDA approved in 2002.<ref>Escitalopram | https://www.drugs.com/cdi/escitalopram.html</ref>

===Fluoxetine===

Fluoxetine is an SSRI commonly sold under the brand name '''Prozac'''. Fluoxetine is indicated for the treatment of major depressive disorder, bulimia nervosa, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is sometimes used in conjunction with olanzapine (an atypical antipsychotic) to treat bipolar I disorder as well as treatment-resistant depression.<ref> Fluoxetine | https://www.drugs.com/fluoxetine.html</ref>A single pill medication called '''Symbyax''' is a combination of olanzapine and fluoxetine.<ref> Symbyax Prescribing Information | http://pi.lilly.com/us/symbyax-pi.pdf</ref>Fluoxetine is on the World Health Organization's list of essential medicines, a list of medicines needed for a basic and effective health system.<ref> WHO List of Essential Medicines | http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref>Fluoxetine was first FDA approved in 1987.

Fluoxetine is an SSRI commonly sold under the brand name '''Prozac'''. Fluoxetine is indicated for the treatment of major depressive disorder, bulimia nervosa, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is sometimes used in conjunction with olanzapine (an atypical antipsychotic) to treat bipolar I disorder as well as treatment-resistant depression.<ref>Fluoxetine | https://www.drugs.com/fluoxetine.html</ref>A single pill medication called '''Symbyax''' is a combination of olanzapine and fluoxetine.<ref>Symbyax Prescribing Information | http://pi.lilly.com/us/symbyax-pi.pdf</ref>Fluoxetine is on the World Health Organization's list of essential medicines, a list of medicines needed for a basic and effective health system.<ref>WHO List of Essential Medicines | http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref>Fluoxetine was first FDA approved in 1987.

===Fluvoxamine===

Fluvoxamine is an SSRI that is used to treat obsessive-compulsive disorder. Fluvoxamine was first approved by the FDA in 1994.<ref> Fluvoxamine | https://www.drugs.com/cdi/fluvoxamine.html</ref>Fluvoxamine has the greatest affinity for the σ1 (sigma-1) receptor, where it acts as an [[agonist]], which may contribute to its biological effects.<ref> Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. | https://www.ncbi.nlm.nih.gov/pubmed/20021354</ref>

Fluvoxamine is an SSRI that is used to treat obsessive-compulsive disorder. Fluvoxamine was first approved by the FDA in 1994.<ref>Fluvoxamine | https://www.drugs.com/cdi/fluvoxamine.html</ref>Fluvoxamine has the greatest affinity for the σ1 (sigma-1) receptor, where it acts as an [[agonist]], which may contribute to its biological effects.<ref>Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. | https://www.ncbi.nlm.nih.gov/pubmed/20021354</ref>

===Paroxetine===

Paroxetine is an SSRI that is sold under the brand name '''Paxil'''. Paroxetine is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, premenstrual dysphoric disorder, and under the brand name '''Brisdelle''', it is used to treat hot flashes related to menopause. Paroxetine was first approved by the FDA in 1992.<ref> Paroxetine | https://www.drugs.com/paroxetine.html</ref>

Paroxetine is an SSRI that is sold under the brand name '''Paxil'''. Paroxetine is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, premenstrual dysphoric disorder, and under the brand name '''Brisdelle''', it is used to treat hot flashes related to menopause. Paroxetine was first approved by the FDA in 1992.<ref>Paroxetine | https://www.drugs.com/paroxetine.html</ref>

===Sertraline===

Sertraline is an SSRI that is sold under the brand name '''Zoloft'''. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, panic disorder, and premenstrual dysphoric disorder. Sertraline was first FDA approved in 1991.<ref> Sertraline | https://www.drugs.com/sertraline.html</ref>Unlike most SSRIs, sertraline, has somewhat significant activity at the [[dopamine]] transporter protein<ref> Second generation SSRI: human monoamine transporter binding profile of escitalopram and R-fluoxetine | https://www.ncbi.nlm.nih.gov/pubmed/12232544</ref> and could be considered a serotonin-dopamine reuptake inhibitor.

Sertraline is an SSRI that is sold under the brand name '''Zoloft'''. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, panic disorder, and premenstrual dysphoric disorder. Sertraline was first FDA approved in 1991.<ref>Sertraline | https://www.drugs.com/sertraline.html</ref>Unlike most SSRIs, sertraline, has somewhat significant activity at the [[dopamine]] transporter protein<ref>Second generation SSRI: human monoamine transporter binding profile of escitalopram and R-fluoxetine | https://www.ncbi.nlm.nih.gov/pubmed/12232544</ref> and could be considered a serotonin-dopamine reuptake inhibitor.

===Other SSRIs===

@@ Line 53: / Line 53: @@
 *'''[[Effect::Depression]]'''
 *'''[[Effect::Anxiety]]'''
+*'''[[Effect::Mindfulness supression]]'''
+*'''[[Effect::Irritability]]'''
+*'''[[Effect::Motivation suppression]]'''
 *'''[[Effect::Suicidal ideation]]''' <ref>Björkenstam, C., Möller, J., Gunilla Ringbäck, G., Salmi, P., Hallgvist, J., & Ljung, R. (2013, September 9). An Association between Initiation of Selective Serotonin Reuptake Inhibitors and Suicide - A Nationwide Register-Based Case-Crossover Study. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767591/</ref> - Upon first introduction, some users (especially people under the age of 25)<ref>https://www.mayoclinic.org/diseases-conditions/teen-depression/in-depth/antidepressants/art-20047502</ref> can experience increase suicidal and self harming thoughts and behaviors. This effect usually subsides within 6-8 weeks.
 *'''[[Effect::Insomnia]]'''
@@ Line 64: / Line 67: @@
 ==Examples==
 ===Citalopram===
-Citalopram is an SSRI sold under the brand name '''Celexa''' in the United States. Citalopram is indicated for the treatment of a major depressive disorder. Citalopram was approved in 1998 by the Food and Drug Administration for the treatment of major depressive disorder.<ref>Nemeroff, CB (2012). Management of Treatment-Resistant Major Psychiatric Disorders. USA: Oxford University Press. p. 30.</ref> Citalopram is almost exclusively found as the hydrobromide salt, which is the only form approved by the FDA.<ref> Citalopram | https://www.drugs.com/citalopram.html</ref>
+Citalopram is an SSRI sold under the brand name '''Celexa''' in the United States. Citalopram is indicated for the treatment of a major depressive disorder. Citalopram was approved in 1998 by the Food and Drug Administration for the treatment of major depressive disorder.<ref>Nemeroff, CB (2012). Management of Treatment-Resistant Major Psychiatric Disorders. USA: Oxford University Press. p. 30.</ref> Citalopram is almost exclusively found as the hydrobromide salt, which is the only form approved by the FDA.<ref>Citalopram | https://www.drugs.com/citalopram.html</ref>
 ===Escitalopram===
-Escitalopram is an SSRI sold under the brand name '''Lexapro''' in the United States. Escitalopram is indicated for the treatment of major depressive disorder and anxiety disorders. It is the s-enantiomer of citalopram, and both have similar efficacy. Escitalopram was FDA approved in 2002.<ref> Escitalopram | https://www.drugs.com/cdi/escitalopram.html</ref>
+Escitalopram is an SSRI sold under the brand name '''Lexapro''' in the United States. Escitalopram is indicated for the treatment of major depressive disorder and anxiety disorders. It is the s-enantiomer of citalopram, and both have similar efficacy. Escitalopram was FDA approved in 2002.<ref>Escitalopram | https://www.drugs.com/cdi/escitalopram.html</ref>
 ===Fluoxetine===
-Fluoxetine is an SSRI commonly sold under the brand name '''Prozac'''. Fluoxetine is indicated for the treatment of major depressive disorder, bulimia nervosa, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is sometimes used in conjunction with olanzapine (an atypical antipsychotic) to treat bipolar I disorder as well as treatment-resistant depression.<ref> Fluoxetine | https://www.drugs.com/fluoxetine.html</ref>A single pill medication called '''Symbyax''' is a combination of olanzapine and fluoxetine.<ref> Symbyax Prescribing Information | http://pi.lilly.com/us/symbyax-pi.pdf</ref>Fluoxetine is on the World Health Organization's list of essential medicines, a list of medicines needed for a basic and effective health system.<ref> WHO List of Essential Medicines | http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref>Fluoxetine was first FDA approved in 1987.
+Fluoxetine is an SSRI commonly sold under the brand name '''Prozac'''. Fluoxetine is indicated for the treatment of major depressive disorder, bulimia nervosa, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is sometimes used in conjunction with olanzapine (an atypical antipsychotic) to treat bipolar I disorder as well as treatment-resistant depression.<ref>Fluoxetine | https://www.drugs.com/fluoxetine.html</ref>A single pill medication called '''Symbyax''' is a combination of olanzapine and fluoxetine.<ref>Symbyax Prescribing Information | http://pi.lilly.com/us/symbyax-pi.pdf</ref>Fluoxetine is on the World Health Organization's list of essential medicines, a list of medicines needed for a basic and effective health system.<ref>WHO List of Essential Medicines | http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref>Fluoxetine was first FDA approved in 1987.
 ===Fluvoxamine===
-Fluvoxamine is an SSRI that is used to treat obsessive-compulsive disorder. Fluvoxamine was first approved by the FDA in 1994.<ref> Fluvoxamine | https://www.drugs.com/cdi/fluvoxamine.html</ref>Fluvoxamine has the greatest affinity for the σ1 (sigma-1) receptor, where it acts as an [[agonist]], which may contribute to its biological effects.<ref> Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. | https://www.ncbi.nlm.nih.gov/pubmed/20021354</ref>
+Fluvoxamine is an SSRI that is used to treat obsessive-compulsive disorder. Fluvoxamine was first approved by the FDA in 1994.<ref>Fluvoxamine | https://www.drugs.com/cdi/fluvoxamine.html</ref>Fluvoxamine has the greatest affinity for the σ1 (sigma-1) receptor, where it acts as an [[agonist]], which may contribute to its biological effects.<ref>Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. | https://www.ncbi.nlm.nih.gov/pubmed/20021354</ref>
 ===Paroxetine===
-Paroxetine is an SSRI that is sold under the brand name '''Paxil'''. Paroxetine is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, premenstrual dysphoric disorder, and under the brand name '''Brisdelle''', it is used to treat hot flashes related to menopause. Paroxetine was first approved by the FDA in 1992.<ref> Paroxetine | https://www.drugs.com/paroxetine.html</ref>
+Paroxetine is an SSRI that is sold under the brand name '''Paxil'''. Paroxetine is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, premenstrual dysphoric disorder, and under the brand name '''Brisdelle''', it is used to treat hot flashes related to menopause. Paroxetine was first approved by the FDA in 1992.<ref>Paroxetine | https://www.drugs.com/paroxetine.html</ref>
 ===Sertraline===
-Sertraline is an SSRI that is sold under the brand name '''Zoloft'''. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, panic disorder, and premenstrual dysphoric disorder. Sertraline was first FDA approved in 1991.<ref> Sertraline | https://www.drugs.com/sertraline.html</ref>Unlike most SSRIs, sertraline, has somewhat significant activity at the [[dopamine]] transporter protein<ref> Second generation SSRI: human monoamine transporter binding profile of escitalopram and R-fluoxetine | https://www.ncbi.nlm.nih.gov/pubmed/12232544</ref> and could be considered a serotonin-dopamine reuptake inhibitor.
+Sertraline is an SSRI that is sold under the brand name '''Zoloft'''. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, panic disorder, and premenstrual dysphoric disorder. Sertraline was first FDA approved in 1991.<ref>Sertraline | https://www.drugs.com/sertraline.html</ref>Unlike most SSRIs, sertraline, has somewhat significant activity at the [[dopamine]] transporter protein<ref>Second generation SSRI: human monoamine transporter binding profile of escitalopram and R-fluoxetine | https://www.ncbi.nlm.nih.gov/pubmed/12232544</ref> and could be considered a serotonin-dopamine reuptake inhibitor.
 ===Other SSRIs===