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Harmala alkaloid: Difference between revisions
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
===Drug interactions=== | ===Drug interactions=== | ||
While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs.<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref> In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc. Sedatives are likely easier tolerated, but potentiation should be expected. | While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs.<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref> In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc. Sedatives are likely easier tolerated, but potentiation should be expected. | ||
===Cholinergics=== | |||
Acetylcholinesterase inhibitors (AChEIs) combined with [[cholinergic]] substances can result in a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis] | |||
Banisteriopsis caapi and ''[[Peganum harmala]]'' contains harmaline and harmine. Both alkaloids are acetylcholinesterase inhibitors (AChEIs).<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref> | |||
===Lethal dosage=== | ===Lethal dosage=== | ||