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Peganum harmala: Difference between revisions
>David Hedlund Desoxypeganine is a selective MAO-A inhibitor |
>David Hedlund Added ===Dangerous interactions=== ====Cholinergics==== |
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*Vasicinone,<ref name=nook/> 0.0007%<ref name=chroma/> | *Vasicinone,<ref name=nook/> 0.0007%<ref name=chroma/> | ||
==Drug use in pregnancy== | ==Toxicity and harm potential== | ||
===Dangerous interactions=== | |||
====Cholinergics==== | |||
[[Cholinergic]] substances combined with ''Peganum harmala'' can cause a cholinergic crisis because the plant contains several acetylcholinesterase inhibitors: | |||
* Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref> | |||
* Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref> | |||
* Harmine<ref name="Pubmed-19784581" /> | |||
* Harmol<ref name="Pubmed-19784581" /> | |||
* Vasicine (possible)<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366</ref> | |||
====Drug use in pregnancy==== | |||
''Peganum harmala'' can induce miscarriage. It has traditionally been used as an abortifacient agent in Morocco, North Africa, and the Middle East.<ref>https://www.hindawi.com/journals/criem/2014/783236/</ref> It is believed that quinazoline alkaloids such as vasicine and vasicinone are responsible for the abortifacient activity of the plant.<ref>https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/zygophyllaceae</ref> | ''Peganum harmala'' can induce miscarriage. It has traditionally been used as an abortifacient agent in Morocco, North Africa, and the Middle East.<ref>https://www.hindawi.com/journals/criem/2014/783236/</ref> It is believed that quinazoline alkaloids such as vasicine and vasicinone are responsible for the abortifacient activity of the plant.<ref>https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/zygophyllaceae</ref> | ||