25I-NBOMe: Difference between revisions

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Tolerance to the effects of 25I-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25I-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.

===Overose===

Due to the very high potency and seemingly unpredictable effects the margin between a normal and an overdose of 25i-NBOMe is extremely small when compared to many other substances. The exact toxic dose is unclear since it seems to depend a lot on personal physiology, rather than predominantly dosage, but various anecdotal reports suggest dangerous side effects when exceeding 1 milligram and it possibly becoming lethal for the more sensitive people at roughly 2 milligrams. Reports of other people surviving much higher doses, sometimes even without side effects has been documented as well. There is also the uncertainty of dosage on blotter paper since it is rather difficult to lay such an exact dosage. Insufflating, vaporizing or drinking tinctures of this substance is highly discouraged because of this.

The overdose effects of 25i-NBOMe are typically a dangerously high [[Increased ~~Heart Rate~~|heart rate]], [[Increased blood pressure|blood pressure]], [[hyperthermia]] and significant [[vasoconstriction]]{{citation needed}} also accompanied by [[confusion]], [[delusions]], [[panic attack]]s, aggressive behavior, [[Tactile suppression|numbness]] or pain, [[amnesia]] and often [[seizure]]s. The risks in an overdose include anything from organ failure to cardiac arrest and death{{citation needed}}. There are also reports of people lethally injuring themselves or falling to death{{citation needed}}. [[Benzodiazepines]] or [[antipsychotics]] can help with the psychological effects during an overdose although medical attention should always be called in even a possible overdose of 25i-~~NBOME~~.

The overdose effects of 25i-NBOMe are typically a dangerously high [[Increased heart rate|heart rate]], [[Increased blood pressure|blood pressure]], [[hyperthermia]] and significant [[vasoconstriction]]{{citation needed}} also accompanied by [[confusion]], [[delusions]], [[panic attack]]s, aggressive behavior, [[Tactile suppression|numbness]] or pain, [[amnesia]] and often [[seizure]]s. The risks in an overdose include anything from organ failure to cardiac arrest and death{{citation needed}}. There are also reports of people lethally injuring themselves or falling to death{{citation needed}}. [[Benzodiazepines]] or [[antipsychotics]] can help with the psychological effects during an overdose although medical attention should always be called in even a possible overdose of 25i-NBOMe.

===Dangerous interactions===

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 Tolerance to the effects of 25I-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25I-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.
 ===Overose===
 Due to the very high potency and seemingly unpredictable effects the margin between a normal and an overdose of 25i-NBOMe is extremely small when compared to many other substances. The exact toxic dose is unclear since it seems to depend a lot on personal physiology, rather than predominantly dosage, but various anecdotal reports suggest dangerous side effects when exceeding 1 milligram and it possibly becoming lethal for the more sensitive people at roughly 2 milligrams. Reports of other people surviving much higher doses, sometimes even without side effects has been documented as well. There is also the uncertainty of dosage on blotter paper since it is rather difficult to lay such an exact dosage. Insufflating, vaporizing or drinking tinctures of this substance is highly discouraged because of this.
-The overdose effects of 25i-NBOMe are typically a dangerously high [[Increased Heart Rate|heart rate]], [[Increased blood pressure|blood pressure]], [[hyperthermia]] and significant [[vasoconstriction]]{{citation needed}} also accompanied by [[confusion]], [[delusions]], [[panic attack]]s, aggressive behavior, [[Tactile suppression|numbness]] or pain, [[amnesia]] and often [[seizure]]s. The risks in an overdose include anything from organ failure to cardiac arrest and death{{citation needed}}. There are also reports of people lethally injuring themselves or falling to death{{citation needed}}. [[Benzodiazepines]] or [[antipsychotics]] can help with the psychological effects during an overdose although medical attention should always be called in even a possible overdose of 25i-NBOME.
+The overdose effects of 25i-NBOMe are typically a dangerously high [[Increased heart rate|heart rate]], [[Increased blood pressure|blood pressure]], [[hyperthermia]] and significant [[vasoconstriction]]{{citation needed}} also accompanied by [[confusion]], [[delusions]], [[panic attack]]s, aggressive behavior, [[Tactile suppression|numbness]] or pain, [[amnesia]] and often [[seizure]]s. The risks in an overdose include anything from organ failure to cardiac arrest and death{{citation needed}}. There are also reports of people lethally injuring themselves or falling to death{{citation needed}}. [[Benzodiazepines]] or [[antipsychotics]] can help with the psychological effects during an overdose although medical attention should always be called in even a possible overdose of 25i-NBOMe.
 ===Dangerous interactions===