RIMA: Difference between revisions

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'''Reversible inhibitors of monoamine oxidase A''' (RIMAs) are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A (MAO-A). They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share due to limited efficacy relative to other antidepressants. Because of their reversibility and selectivity, RIMAs are safer than the older [[MAOI|monoamine oxidase inhibitors]] (MAOIs).<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833271/</ref>

While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause [[serotonin#serotonin syndrome|serotonin syndrome]] or hypertensive crisis when combined with almost any antidepressant or [[stimulant]], common migraine medications, certain herbs, or even most cold medicines (including decongestants, [[antihistamines]], and cough syrup).

==Interactions==

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{{For|psychoactive substance interactions (but not food interactions)|MAOI#Interactions}}

While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause [[serotonin#serotonin syndrome|serotonin syndrome]] or hypertensive crisis when combined with almost any antidepressant or [[stimulant]], common migraine medications, certain herbs, or even most cold medicines (including decongestants, [[antihistamines]], and cough syrup).

==List of RIMAs==

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 '''Reversible inhibitors of monoamine oxidase A''' (RIMAs) are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A (MAO-A). They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share due to limited efficacy relative to other antidepressants. Because of their reversibility and selectivity, RIMAs are safer than the older [[MAOI|monoamine oxidase inhibitors]] (MAOIs).<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833271/</ref>
-While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause [[serotonin#serotonin syndrome|serotonin syndrome]] or hypertensive crisis when combined with almost any antidepressant or [[stimulant]], common migraine medications, certain herbs, or even most cold medicines (including decongestants, [[antihistamines]], and cough syrup).
 ==Interactions==
@@ Line 7: / Line 5: @@
 {{For|psychoactive substance interactions (but not food interactions)|MAOI#Interactions}}
+While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause [[serotonin#serotonin syndrome|serotonin syndrome]] or hypertensive crisis when combined with almost any antidepressant or [[stimulant]], common migraine medications, certain herbs, or even most cold medicines (including decongestants, [[antihistamines]], and cough syrup).
 ==List of RIMAs==