MiPLA: Difference between revisions

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~~===Combination effects===~~

*'''[[Alcohol]]''' - Alcohol's central depressant effects can counteract some of the anxiety and bodily tension produced by MiPLA. However, alcohol can cause [[dehydration]], [[nausea]] and [[physical fatigue]] which can negatively impact the tone of the trip. Users are advised to pace themselves and drink a portion of their usual amount.

*'''[[Benzodiazepines]]''' - Benzodiazepines are highly effective at reducing the intensity of MiPLA's effects through the general suppression of brain activity.

*'''[[Cannabis]]''' - Cannabis strongly intensifies the sensory and cognitive effects of MiPLA. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.

*'''[[Dissociatives]]''' - MiPLA enhances the cognitive, visual and general hallucinatory effects of dissociatives. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] and [[internal hallucinations]] become more vivid and intense on MiPLA. These effects correspond with an increased risk of [[confusion]], [[delusions]], and [[psychosis]].

*'''[[MDMA]]''' - MiPLA and MDMA are highly synergistic and mutually enhance each other's physical, cognitive, and visual effects. The synergy between these substances is unpredictable so it is advised to start with markedly lower doses than one would take for each individually. There is some evidence that suggests that co-administration of LSD with MDMA increases the neurotoxicity of the latter,<ref>Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptor partial agonist d‐lysergic acid diethylamide (MiPLA), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023</ref><ref>Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine</ref><ref>Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501</ref> and this may extend to MiPLA.

===Experience reports===

There are currently {{#ask:[[Category:MiPLA]][[Category:Experience]] | format=count}} anecdotal reports which describe the effects of this compound within our [[experience index]].

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-===Combination effects===
-*'''[[Alcohol]]''' - Alcohol's central depressant effects can counteract some of the anxiety and bodily tension produced by MiPLA. However, alcohol can cause [[dehydration]], [[nausea]] and [[physical fatigue]] which can negatively impact the tone of the trip. Users are advised to pace themselves and drink a portion of their usual amount.
-*'''[[Benzodiazepines]]''' - Benzodiazepines are highly effective at reducing the intensity of MiPLA's effects through the general suppression of brain activity.
-*'''[[Cannabis]]''' - Cannabis strongly intensifies the sensory and cognitive effects of MiPLA. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.
-*'''[[Dissociatives]]''' - MiPLA enhances the cognitive, visual and general hallucinatory effects of dissociatives. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] and [[internal hallucinations]] become more vivid and intense on MiPLA. These effects correspond with an increased risk of [[confusion]], [[delusions]], and [[psychosis]].
-*'''[[MDMA]]''' - MiPLA and MDMA are highly synergistic and mutually enhance each other's physical, cognitive, and visual effects. The synergy between these substances is unpredictable so it is advised to start with markedly lower doses than one would take for each individually. There is some evidence that suggests that co-administration of LSD with MDMA increases the neurotoxicity of the latter,<ref>Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptor partial agonist d‐lysergic acid diethylamide (MiPLA), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023</ref><ref>Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine</ref><ref>Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501</ref> and this may extend to MiPLA.
 ===Experience reports===
 There are currently {{#ask:[[Category:MiPLA]][[Category:Experience]] | format=count}} anecdotal reports which describe the effects of this compound within our [[experience index]].