Mirtazapine: Difference between revisions

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Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>

Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).

Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).{{citation needed}}

Mirtazapine is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for the treatment of

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Although mirtazapine exhibits almost exclusively psychedelic effects, the hallucinations that accompany it do have distinctively deliriant-like effects. For example, they are often delirious in their believability and rarely comprised of condensed visual [[geometry]]. Instead they tend to be solid and extremely realistic in appearance.

The mental processes, thought patterns and general head space experienced during a high dose mirtazapine experience is one that is typically described to be completely devoid of insight. In contrast to many other substances with hallucinogenic properties, it produces no [[introspection]], [[personal bias suppression|personal problem solving]] or [[creativity enhancement|creativity enhancing]] effects; for this reason it is generally reported that mirtazapine holds ~~absolutely~~ no therapeutic potential when used as a [[hallucinogen]].

The mental processes, thought patterns and general head space experienced during a high dose mirtazapine experience is one that is typically described to be completely devoid of insight. In contrast to many other substances with hallucinogenic properties, it produces no [[introspection]], [[personal bias suppression|personal problem solving]] or [[creativity enhancement|creativity enhancing]] effects; for this reason it is generally reported that mirtazapine holds no therapeutic potential when used as a [[hallucinogen]].

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*'''[[Effect::Increased music appreciation]]'''

*'''[[Effect::Irritability]]'''

*'''[[Effect::Emotion suppression]]''' - ~~On mirtazapine, like other anti-depressants,~~ emotions ~~are dulled,~~ and it is typically difficult to express them.

*'''[[Effect::Emotion suppression]]''' - Mirtazapine has a dulling effect on emotions and it is typically difficult to express them.

*'''[[Anxiety suppression]]''' - This effect is much stronger and more rapidly acting than that of SSRIs.

}}

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}}

===~~Combinational~~ effects===

===Combination effects===

*'''[[Cannabis]]''' - When mirtazapine is combined with cannabis, the euphoric and visual effects are greatly potentiated.

*'''[[Psychedelics]]''' - Due to mirtazapines action as a 5-HT<sub>2A</sub> antagonist, it can help reduce the intensity or "abort" a [[bad trip]]

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[[File:Mirtazapine FDA prescription guide.jpg|300px|thumbnail|This document, provided with prescription mirtazapine, contains detailed information regrading its toxicity and harm potential.]]

Mirtazapine is not known to cause brain damage, and has extremely low toxicity relative to dose. Similar to other [[psychedelic]] drugs, there are relatively few physical side effects associated with mirtazapine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.

===Dependence and abuse potential===

Mirtazapine is [[Addiction potential::not habit-forming]] when used as a hallucinogen and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of mirtazapine are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). Mirtazapine presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of mirtazapine all psychedelics will have a reduced effect.

===Overdose===

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It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

~~===Tolerance and addiction potential===~~

~~Mirtazapine is [[Addiction potential::not habit-forming]] when used as a hallucinogen and the desire to use it can actually decrease with use. It is most often self-regulating.~~

Tolerance to the effects of mirtazapine are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). Mirtazapine presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of mirtazapine all psychedelics will have a reduced effect.

===Dangerous interactions===

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Mirtazapine is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription.

*'''United Kingdom''' ~~- This substance~~ is a licensed prescription-only medicine (POM) in the United Kingdom.<ref>{{cite web |url = http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con2025201.pdf|title = MHRA license for Modafinil in UK|date = November 10, 2006|author = MHRA|publisher = MHRA}}</ref> It is not a criminal offence to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>

*'''United Kingdom:''' Mirtazapine is a licensed prescription-only medicine (POM) in the United Kingdom.<ref>{{cite web |url = http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con2025201.pdf|title = MHRA license for Modafinil in UK|date = November 10, 2006|author = MHRA|publisher = MHRA}}</ref> It is not a criminal offence to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>

==See also==

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*[http://www.erowid.org/pharms/mirtazapine/mirtazapine.shtml Mirtazapine (Erowid Vault)]

*[http://www.drugs.com/mirtazapine.html Mirtazapine (Drugs.com)]

===~~Community~~===

===Discussion===

*[http://disregardeverythingisay.com/post/43240860676/mirtazapine-broken-down-and-described Mirtazapine, broken down and described (Disregard Everything I Say)]

@@ Line 6: / Line 6: @@
 Mirtazapine was developed in the Netherlands and introduced in the United States in 1996.<ref> "REMERON (mirtazapine) tablet, film coated [Organon Pharmaceuticals USA]". DailyMed. Organon Pharmaceuticals USA. October 2012. Retrieved 24 October 2013.</ref> Its patent expired in 2004 and generic versions have been widely available since.<ref>Schatzberg, AF; Cole, JO; DeBattista, C. "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing.</ref>
-Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
+Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).{{citation needed}}
 Mirtazapine is used primarily in the treatment of major depressive disorder and other mood disorders.<ref>Mirtazapine: clinical overview. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10446735</ref><ref>Review of the use of mirtazapine in the treatment of depression | http://informahealthcare.com/doi/abs/10.1517/14656566.2011.585459</ref> However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for the treatment of
@@ Line 54: / Line 54: @@
 Although mirtazapine exhibits almost exclusively psychedelic effects, the hallucinations that accompany it do have distinctively deliriant-like effects. For example, they are often delirious in their believability and rarely comprised of condensed visual [[geometry]]. Instead they tend to be solid and extremely realistic in appearance.
-The mental processes, thought patterns and general head space experienced during a high dose mirtazapine experience is one that is typically described to be completely devoid of insight. In contrast to many other substances with hallucinogenic properties, it produces no [[introspection]], [[personal bias suppression|personal problem solving]] or [[creativity enhancement|creativity enhancing]] effects; for this reason it is generally reported that mirtazapine holds absolutely no therapeutic potential when used as a [[hallucinogen]].
+The mental processes, thought patterns and general head space experienced during a high dose mirtazapine experience is one that is typically described to be completely devoid of insight. In contrast to many other substances with hallucinogenic properties, it produces no [[introspection]], [[personal bias suppression|personal problem solving]] or [[creativity enhancement|creativity enhancing]] effects; for this reason it is generally reported that mirtazapine holds no therapeutic potential when used as a [[hallucinogen]].
 {{Preamble/SubjectiveEffects}}
@@ Line 92: / Line 92: @@
 *'''[[Effect::Increased music appreciation]]'''
 *'''[[Effect::Irritability]]'''
-*'''[[Effect::Emotion suppression]]''' - On mirtazapine, like other anti-depressants, emotions are dulled, and it is typically difficult to express them.
+*'''[[Effect::Emotion suppression]]''' - Mirtazapine has a dulling effect on emotions and it is typically difficult to express them.
 *'''[[Anxiety suppression]]''' - This effect is much stronger and more rapidly acting than that of SSRIs.
 }}
@@ Line 116: / Line 116: @@
 }}
-===Combinational effects===
+===Combination effects===
 *'''[[Cannabis]]''' - When mirtazapine is combined with cannabis, the euphoric and visual effects are greatly potentiated.
 *'''[[Psychedelics]]''' - Due to mirtazapines action as a 5-HT<sub>2A</sub> antagonist, it can help reduce the intensity or "abort" a [[bad trip]]
@@ Line 129: / Line 129: @@
 [[File:Mirtazapine FDA prescription guide.jpg|300px|thumbnail|This document, provided with prescription mirtazapine, contains detailed information regrading its toxicity and harm potential.]]
 Mirtazapine is not known to cause brain damage, and has extremely low toxicity relative to dose. Similar to other [[psychedelic]] drugs, there are relatively few physical side effects associated with mirtazapine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.
+===Dependence and abuse potential===
+Mirtazapine is [[Addiction potential::not habit-forming]] when used as a hallucinogen and the desire to use it can actually decrease with use. It is most often self-regulating.
+Tolerance to the effects of mirtazapine are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). Mirtazapine presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of mirtazapine all psychedelics will have a reduced effect.
 ===Overdose===
@@ Line 136: / Line 141: @@
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
-===Tolerance and addiction potential===
-Mirtazapine is [[Addiction potential::not habit-forming]] when used as a hallucinogen and the desire to use it can actually decrease with use. It is most often self-regulating.
-Tolerance to the effects of mirtazapine are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). Mirtazapine presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of mirtazapine all psychedelics will have a reduced effect.
 ===Dangerous interactions===
@@ Line 149: / Line 149: @@
 Mirtazapine is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription.
-*'''United Kingdom''' - This substance is a licensed prescription-only medicine (POM) in the United Kingdom.<ref>{{cite web |url = http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con2025201.pdf|title = MHRA license for Modafinil in UK|date = November 10, 2006|author = MHRA|publisher = MHRA}}</ref> It is not a criminal offence to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>
+*'''United Kingdom:''' Mirtazapine is a licensed prescription-only medicine (POM) in the United Kingdom.<ref>{{cite web |url = http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con2025201.pdf|title = MHRA license for Modafinil in UK|date = November 10, 2006|author = MHRA|publisher = MHRA}}</ref> It is not a criminal offence to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.<ref>{{cite web |url = http://www.legislation.gov.uk/ukpga/1968/67/section/13|title = Medicines Act 1968 Section 13}}</ref>
 ==See also==
@@ Line 161: / Line 161: @@
 *[http://www.erowid.org/pharms/mirtazapine/mirtazapine.shtml Mirtazapine (Erowid Vault)]
 *[http://www.drugs.com/mirtazapine.html Mirtazapine (Drugs.com)]
-===Community===
+===Discussion===
 *[http://disregardeverythingisay.com/post/43240860676/mirtazapine-broken-down-and-described Mirtazapine, broken down and described (Disregard Everything I Say)]