MiPLA: Difference between revisions

Line 132:

Additional experience reports can be found here:

* [https://www.erowid.org/experiences/subs/exp_ALLAD.shtml Erowid Experience Vaults: MiPLA]

==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational MiPLA use has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because MiPLA is a [[research chemical]] with very little history of human usage.

The body of anecdotal reports suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

As with other psychedelic substances, there are relatively few physical side effects that have been reported associated with acute MiPLA exposure. Although no formal studies have been conducted, it is likely that as with [[LSD]] itself, MiPLA is able to be considered non-addictive, with an [[Toxicity::extremely low toxicity]] relative to dose.<ref>Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008). [http://www.maps.org/w3pb/new/2008/2008_Passie_23067_1.pdf The Pharmacology of Lysergic Acid Diethylamide: A Review], 14, 295–314. https://doi.org/10.1111/j.1755-5949.2008.00059.x</ref> It is also likely that as with LSD, there are little to no negative physical, cognitive, psychiatric or other toxic consequences associated with acute MiPLA exposure.

However, as with LSD and psychedelics in general, it is possible that MiPLA can act as a potential trigger for those with underlying psychiatric conditions. Those with a personal or family history of mental illness are generally advised not to use this substance, particularly outside of a supervised medical setting.

It is strongly recommended that one uses [[responsible drug use|harm reduction practices]] when using this substance.

===Tolerance and addiction potential===

Although no formal studies have been conducted, it is not unreasonable to assume that as with LSD itself, MiPLA is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use.

Tolerance to the effects of MiPLA are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::5-7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::14 days]] to be back at baseline (in the absence of further consumption). MiPLA presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the use of MiPLA all psychedelics will have a reduced effect.

Owing to its activity at the 5-HT<sub>2A</sub> receptor, MiPLA presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of MiPLA all psychedelics will have a reduced effect.

===Overdose===

The LD<sub>50</sub> of MiPLA is unknown. Adverse psychological reactions are common especially at higher dosages. Some of these include [[anxiety]], [[delusions]], [[panic attacks]] and more rarely [[seizures]]. Medical attention is usually only needed if suspected of severe psychotic episodes or “fake acid” (such as [[25i-NBOMe]] or [[DOB]]). Administration of [[benzodiazepines]] or [[antipsychotics]] can help to relieve the negative cognitive effects of MiPLA.

===Dangerous interactions===

*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}

*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}

==Literature==

@@ Line 132: / Line 132: @@
 Additional experience reports can be found here:
 * [https://www.erowid.org/experiences/subs/exp_ALLAD.shtml Erowid Experience Vaults: MiPLA]
+==Toxicity and harm potential==
+{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
+The toxicity and long-term health effects of recreational MiPLA use has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because MiPLA is a [[research chemical]] with very little history of human usage.
+The body of anecdotal reports suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+As with other psychedelic substances, there are relatively few physical side effects that have been reported associated with acute MiPLA exposure. Although no formal studies have been conducted, it is likely that as with [[LSD]] itself, MiPLA is able to be considered non-addictive, with an [[Toxicity::extremely low toxicity]] relative to dose.<ref>Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008). [http://www.maps.org/w3pb/new/2008/2008_Passie_23067_1.pdf The Pharmacology of Lysergic Acid Diethylamide: A Review], 14, 295–314. https://doi.org/10.1111/j.1755-5949.2008.00059.x</ref> It is also likely that as with LSD, there are little to no negative physical, cognitive, psychiatric or other toxic consequences associated with acute MiPLA exposure.
+However, as with LSD and psychedelics in general, it is possible that MiPLA can act as a potential trigger for those with underlying psychiatric conditions. Those with a personal or family history of mental illness are generally advised not to use this substance, particularly outside of a supervised medical setting.
+It is strongly recommended that one uses [[responsible drug use|harm reduction practices]] when using this substance.
+===Tolerance and addiction potential===
+Although no formal studies have been conducted, it is not unreasonable to assume that as with LSD itself, MiPLA is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use.
+Tolerance to the effects of MiPLA are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::5-7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::14 days]] to be back at baseline (in the absence of further consumption). MiPLA presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the use of MiPLA all psychedelics will have a reduced effect.
+Owing to its activity at the 5-HT<sub>2A</sub> receptor, MiPLA presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of MiPLA all psychedelics will have a reduced effect.
+===Overdose===
+The LD<sub>50</sub> of MiPLA is unknown. Adverse psychological reactions are common especially at higher dosages. Some of these include [[anxiety]], [[delusions]], [[panic attacks]] and more rarely [[seizures]]. Medical attention is usually only needed if suspected of severe psychotic episodes or “fake acid” (such as [[25i-NBOMe]] or [[DOB]]). Administration of [[benzodiazepines]] or [[antipsychotics]] can help to relieve the negative cognitive effects of MiPLA.
+===Dangerous interactions===
+{{DangerousInteractions/Intro}}
+*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
+*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
+*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
 ==Literature==