MiPLA: Difference between revisions

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Methylisopropyllysergamide (also known as Lamide or as it's most commonly known MiPLA) is a novel psychedelic substance of the lysergamide class. MiPLA is chemically similar to LSD and has a similar mechanism of action, working primarily by binding to serotonin receptors in the brain.

MiPLA is ~~an analogue of LSD first discovered by Albert Hoffman at Sandoz as~~ a ~~part~~ of the ~~original structure-activity research into LSD, more recently it has been researched in greater detail by David E. Nichols at Purdue University~~. MiPLA and ~~its effects are also documented in Alexander Shulgins Pharmacology notes #9 and Pharmacology notes C~~, ~~although not~~ in ~~great detail the reports provide a rough outline of~~ the ~~drugs effects~~.

'''N-Methyl-N-isopropyllysergamide''' (also known as '''methylisopropyllysergamide''', '''Lamide''' and '''MiPLA''') is a novel [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. MiPLA is chemically similar to LSD and has a similar mechanism of action, working primarily by stimulating [[serotonin]] [[receptors]] in the brain.

User reports describe the effects of MiPLA as similar to those of LSD with major differences. It is thought to be 1/3rd as potent as [[LSD]] itself, with an active dose reported at between 100-200 micrograms. It is often described as being more mentally and physically oriented but with a less introspective headspace and subtle, albeit pronounced visuals. It also has a notably shorter duration at 4-5 hours and is generally described as less anxiety-provoking than other lysergamides.

MiPLA was first discovered by Albert Hoffman as a part of the original structure-activity research into LSD. It has recently been researched in greater detail by by the team led by David E. Nichols at Purdue University. MiPLA and its effects are also mentioned in Alexander Shulgin's Pharmacology notes #9 and Pharmacology notes C,

User reports describe the effects of MiPLA as similar to those of LSD with major differences. It is thought to be 1/3rd as potent as [[LSD]] itself, with an active dose reported at between 100-200 micrograms. It is often described as being more mentally and physically oriented but with a less introspective headspace and subtle, albeit pronounced visuals. It also has a notably shorter duration at 4-6 hours and is generally described as less anxiety-provoking than other lysergamides.

Very little data exists about the pharmacological properties, metabolism, and toxicity of MiPLA. While it is often characterized by users as being generally more recreational and non-threatening compared to [[LSD]], it is highly advised to approach this highly potent [[hallucinogenic]] substance with the proper amount of precaution and [[harm reduction practices]] if using it.

==Chemistry==

MiPLA, or methylisopropyllysergamide, is a semi-synthetic alkaloid belonging to the lysergamide chemical class. MiPLA is a structural analogue of

==Pharmacology==

==Subjective effects==

==Literature==

* Halberstadt, A. L., Klein, L. M., Chatha, M., Valenzuela, L. B., Stratford, A., Wallach, J., ... & Brandt, S. D. (2018). Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology, 1-10.

==Further reading==

* [https://heffter.org/docs/hrireview/02/chap6.pdf Nichols, D. E. (2001). LSD and its lysergamide cousins. The Heffter Review of Psychedelic Research. Santa Fe, New Mexico: Heffter Research Institute, 80-87.]

==References==

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-<!-- This page is incomplete! -->
-Methylisopropyllysergamide (also known as Lamide or as it's most commonly known MiPLA) is a novel psychedelic substance of the lysergamide class. MiPLA is chemically similar to LSD and has a similar mechanism of action, working primarily by binding to serotonin receptors in the brain.
-MiPLA is an analogue of LSD first discovered by Albert Hoffman at Sandoz as a part of the original structure-activity research into LSD, more recently it has been researched in greater detail by David E. Nichols at Purdue University. MiPLA  and its effects are also documented in Alexander Shulgins Pharmacology notes #9 and Pharmacology notes C, although not in great detail the reports provide a rough outline of the drugs effects.
+'''N-Methyl-N-isopropyllysergamide''' (also known as '''methylisopropyllysergamide''', '''Lamide''' and '''MiPLA''') is a novel [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. MiPLA is chemically similar to LSD and has a similar mechanism of action, working primarily by stimulating [[serotonin]] [[receptors]] in the brain.
-User reports describe the effects of MiPLA as similar to those of LSD with major differences. It is thought to be 1/3rd as potent as [[LSD]] itself, with an active dose reported at between 100-200 micrograms. It is often described as being more mentally and physically oriented but with a less introspective headspace and subtle, albeit pronounced visuals. It also has a notably shorter duration at 4-5 hours and is generally described as less anxiety-provoking than other lysergamides.
+MiPLA was first discovered by Albert Hoffman as a part of the original structure-activity research into LSD. It has recently been researched in greater detail by by the team led by David E. Nichols at Purdue University. MiPLA and its effects are also mentioned in Alexander Shulgin's Pharmacology notes #9 and Pharmacology notes C,
+User reports describe the effects of MiPLA as similar to those of LSD with major differences. It is thought to be 1/3rd as potent as [[LSD]] itself, with an active dose reported at between 100-200 micrograms. It is often described as being more mentally and physically oriented but with a less introspective headspace and subtle, albeit pronounced visuals. It also has a notably shorter duration at 4-6 hours and is generally described as less anxiety-provoking than other lysergamides.
 Very little data exists about the pharmacological properties, metabolism, and toxicity of MiPLA. While it is often characterized by users as being generally more recreational and non-threatening compared to [[LSD]], it is highly advised to approach this highly potent [[hallucinogenic]] substance with the proper amount of precaution and [[harm reduction practices]] if using it.
+==Chemistry==
+MiPLA, or methylisopropyllysergamide, is a semi-synthetic alkaloid belonging to the lysergamide chemical class. MiPLA is a structural analogue of
+==Pharmacology==
+==Subjective effects==
+==Literature==
+* Halberstadt, A. L., Klein, L. M., Chatha, M., Valenzuela, L. B., Stratford, A., Wallach, J., ... & Brandt, S. D. (2018). Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology, 1-10.
+==Further reading==
+* [https://heffter.org/docs/hrireview/02/chap6.pdf Nichols, D. E. (2001). LSD and its lysergamide cousins. The Heffter Review of Psychedelic Research. Santa Fe, New Mexico: Heffter Research Institute, 80-87.]
+==References==
+<references />