2C-C: Difference between revisions

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2C-C was first synthesized by Alice C. Cheng and Neal Castagnoli Jr. in 1983 as an intermediate in a study evaluating the neurotoxicity of 6-hydroxydopamine analogs.<ref>Cheng, A. C., & Castagnoli Jr, N. (1984). Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2, 5-dihydroxyphenyl)-2-aminoethane analogs of 6-hydroxydopamine. Journal of medicinal chemistry, 27(4), 513-520. https://doi.org/10.1021/jm00370a014</ref> Its activity in humans was later investigated and documented by [[Alexander Shulgin]] in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").

Many users report that the effects of 2C-C are gentler, more relaxed, and [[Sedation|sedating]] than other closely related [[psychedelic]] [[phenethylamines]] such as [[2C-B]], [[2C-I]], and [[2C-E]]. It is ~~considered to be~~ one of the least potent members of the 2C-x family, with muted visual effects and a relatively unaltered headspace.

Many users report that the effects of 2C-C are gentler, more relaxed, and [[Sedation|sedating]] than other closely related [[psychedelic]] [[phenethylamines]] such as [[2C-B]], [[2C-I]], and [[2C-E]]. It is one of the least potent members of the 2C-x family, with muted visual effects and a relatively unaltered headspace.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-C, and its history of human use is limited. Today, it is used for [[recreational drug use|recreational]] and therapeutic purposes. It is rarely sold on the streets and distributed online as a grey area [[research chemical]].

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|{{effects/physical|

*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - In terms of its effects on the physical energy levels of the user, the 2C-C experience typically begins with mild stimulation, but usually becomes somewhat sedating as the experience progresses and lacks the distinctive energetic feeling associated with most [[phenethylamines]]. This is described in [[PiHKAL]] as "''an intense form of relaxation.''"<ref name="isomer">2,5-Dimethoxy-4-chlorophenethylamine (Isomer Design / PiHKAL) | http://isomerdesign.com/PiHKAL/read.php?id=22</ref>

*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - In terms of its effects on the physical energy levels of the user, the 2C-C experience typically begins with mild stimulation, but usually becomes somewhat sedating as the experience progresses and surprisingly lacks the distinctive energetic feeling associated with most [[phenethylamines]]. This is described in [[PiHKAL]] as "''an intense form of relaxation.''"<ref name="isomer">2,5-Dimethoxy-4-chlorophenethylamine (Isomer Design / PiHKAL) | http://isomerdesign.com/PiHKAL/read.php?id=22</ref>

*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-C can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

*'''[[Effect::Tactile enhancement]]'''

*'''[[Effect::Bodily control enhancement]]''' - Whilst at lower doses one may find that their bodily control is enhanced, at higher dosages this becomes suppressed.

*'''[[Effect::~~Temperature regulation suppression~~]]'''

*'''[[Effect::Increased blood pressure]]'''

*'''[[Effect::Increased heart rate]]'''~~{{citation needed}}~~

*'''[[Effect::Increased bodily temperature]]'''

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Increased perspiration]]'''

*'''[[Effect::Nausea]]''' - Although nausea remains present, in comparison to other [[phenethylamines]] such as [[2C-E]], [[2C-I]] or [[2C-B]], this remains relatively mild and tends to dissipate quickly. It is considered by some to be one of the most physically understated [[psychedelics]] known.

*'''[[Effect::Dehydration]]'''

*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Tactile enhancement]]'''

*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of [[MDMA]].

@@ Line 6: / Line 6: @@
 C-C was first synthesized by Alice C. Cheng and Neal Castagnoli Jr. in 1983 as an intermediate in a study evaluating the neurotoxicity of 6-hydroxydopamine analogs.<ref>Cheng, A. C., & Castagnoli Jr, N. (1984). Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2, 5-dihydroxyphenyl)-2-aminoethane analogs of 6-hydroxydopamine. Journal of medicinal chemistry, 27(4), 513-520. https://doi.org/10.1021/jm00370a014</ref> Its activity in humans was later investigated and documented by [[Alexander Shulgin]] in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").
-Many users report that the effects of 2C-C are gentler, more relaxed, and [[Sedation|sedating]] than other closely related [[psychedelic]] [[phenethylamines]] such as [[2C-B]], [[2C-I]], and [[2C-E]]. It is considered to be one of the least potent members of the 2C-x family, with muted visual effects and a relatively unaltered headspace.
+Many users report that the effects of 2C-C are gentler, more relaxed, and [[Sedation|sedating]] than other closely related [[psychedelic]] [[phenethylamines]] such as [[2C-B]], [[2C-I]], and [[2C-E]]. It is one of the least potent members of the 2C-x family, with muted visual effects and a relatively unaltered headspace.
 Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-C, and its history of human use is limited. Today, it is used for [[recreational drug use|recreational]] and therapeutic purposes. It is rarely sold on the streets and distributed online as a grey area [[research chemical]].
@@ Line 23: / Line 23: @@
 |{{effects/physical|
-*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - In terms of its effects on the physical energy levels of the user, the 2C-C experience typically begins with mild stimulation, but usually becomes somewhat sedating as the experience progresses and lacks the distinctive energetic feeling associated with most [[phenethylamines]]. This is described in [[PiHKAL]] as "''an intense form of relaxation.''"<ref name="isomer">2,5-Dimethoxy-4-chlorophenethylamine (Isomer Design / PiHKAL) | http://isomerdesign.com/PiHKAL/read.php?id=22</ref>
+*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - In terms of its effects on the physical energy levels of the user, the 2C-C experience typically begins with mild stimulation, but usually becomes somewhat sedating as the experience progresses and surprisingly lacks the distinctive energetic feeling associated with most [[phenethylamines]]. This is described in [[PiHKAL]] as "''an intense form of relaxation.''"<ref name="isomer">2,5-Dimethoxy-4-chlorophenethylamine (Isomer Design / PiHKAL) | http://isomerdesign.com/PiHKAL/read.php?id=22</ref>
 *'''[[Effect::Spontaneous physical sensations]]''' -  The "body high" of 2C-C can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
-*'''[[Effect::Tactile enhancement]]'''
 *'''[[Effect::Bodily control enhancement]]''' - Whilst at lower doses one may find that their bodily control is enhanced, at higher dosages this becomes suppressed.
-*'''[[Effect::Temperature regulation suppression]]'''
+*'''[[Effect::Increased blood pressure]]'''
-*'''[[Effect::Increased heart rate]]'''{{citation needed}}
+*'''[[Effect::Increased bodily temperature]]'''
+*'''[[Effect::Increased heart rate]]'''
+*'''[[Effect::Increased perspiration]]'''
 *'''[[Effect::Nausea]]''' -  Although nausea remains present, in comparison to other [[phenethylamines]] such as [[2C-E]], [[2C-I]] or [[2C-B]], this remains relatively mild and tends to dissipate quickly. It is considered by some to be one of the most physically understated [[psychedelics]] known.
 *'''[[Effect::Dehydration]]'''
 *'''[[Effect::Pupil dilation]]'''
+*'''[[Effect::Tactile enhancement]]'''
 *'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of [[MDMA]].