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Talk:Positive allosteric modulator: Difference between revisions
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There are many drugs that are positive allosteric modulators. [[Benzodiazepines]] (such as [[diazepam]]), along with [[alcohol]] and [[barbiturates]] (such as [[phenobarbital]]) enhance [[GABA]]. As GABA is the main inhibitory neurotransmitter in the brain, increasing its efficiency causes effects such as [[anxiolysis]], [[sedation]] and [[skeletal muscle relaxation]] <ref>http://www.emcdda.europa.eu/publications/drug-profiles/barbiturates#pharmacology</ref>. | There are many drugs that are positive allosteric modulators. [[Benzodiazepines]] (such as [[diazepam]]), along with [[alcohol]] and [[barbiturates]] (such as [[phenobarbital]]) enhance [[GABA]]. As GABA is the main inhibitory neurotransmitter in the brain, increasing its efficiency causes effects such as [[anxiolysis]], [[sedation]] and [[skeletal muscle relaxation]] <ref>http://www.emcdda.europa.eu/publications/drug-profiles/barbiturates#pharmacology</ref>. | ||
Some [[cannabinoids]] also appear to be PAMs ([[CBD]] is a PAM at two opioid receptors<ref>https://link.springer.com/article/10.1007%2Fs00210-006-0033-x</ref>). This modulation may account for reported [[analgesia]] in cancer patients using CBD oil. | Some [[cannabinoids]] also appear to be PAMs ([[CBD]] is a PAM at two opioid receptors<ref>https://link.springer.com/article/10.1007%2Fs00210-006-0033-x</ref>). This modulation may account for reported [[analgesia]] in cancer patients using CBD oil. | ||
Other substances, such as [[piracetam]] have novel PAM-effects, such as on the [[AMPA]] receptor<ref>https://www.ncbi.nlm.nih.gov/pubmed/20163115</ref> | |||
Other substances, such as [[piracetam]] have novel PAM-effects, such as on the [[AMPA]] receptor<ref>https://www.ncbi.nlm.nih.gov/pubmed/20163115</ref>. | |||
==References== | ==References== | ||