LSA: Difference between revisions

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*'''[[Cannabis]]''' - Cannabis powerfully extends and intensifies both the sensory and cognitive effects of LSA. These substances should be combined with extreme caution as it has been well-observed that they amplify the [[anxiety]], [[confusion]] and [[psychosis]] risk each possess. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose and take at least 20-minute breaks between hits in order to avoid a spiraling negative reaction.

*'''[[Dissociatives]]''' - Dissociatives greatly enhance the cognitive, visuals and general hallucinatory effects of LSA. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of LSA have significantly more vivid visuals than dissociatives alone, as well as more intense [[internal hallucinations]], and corresponding [[confusion]] which can spontaneously manifest as [[delusions]] and [[psychosis]].

*'''[[MDMA]]''' - LSA amplifies the physical, cognitive, and euphoric effects of MDMA. The visual, physical and cognitive effects of LSA can also be intensified to the point of overwhelming euphoric pleasure manifested through unique body highs, mindscapes, and colorful and intricate visuals. The synergy between these substances is unpredictable, and it is advised to start with markedly lower dosages than one would take for both substances individually. The toxicity of this combination is unknown, although there is some evidence that suggests the neurotoxic effects of MDMA may become amplified.<ref>Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023</ref><ref>Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine</ref><ref>Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501</ref>

*'''[[Alcohol]]''' - This combination is not typically recommended due to alcohol’s ability to cause [[dehydration]] and [[nausea]] and [[physical fatigue]] which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, reasonably safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically draining way.

*'''[[Benzodiazepines]]''' - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSA trip. They are very efficient at stopping [[bad trip|"bad trips"]] at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addictive potential that benzodiazepines possess.

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 *'''[[Cannabis]]''' - Cannabis powerfully extends and intensifies both the sensory and cognitive effects of LSA. These substances should be combined with extreme caution as it has been well-observed that they amplify the [[anxiety]], [[confusion]] and [[psychosis]] risk each possess. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose and take at least 20-minute breaks between hits in order to avoid a spiraling negative reaction.
 *'''[[Dissociatives]]''' - Dissociatives greatly enhance the cognitive, visuals and general hallucinatory effects of LSA. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of LSA have significantly more vivid visuals than dissociatives alone, as well as more intense [[internal hallucinations]], and corresponding [[confusion]] which can spontaneously manifest as [[delusions]] and [[psychosis]].
-*'''[[MDMA]]''' - LSA amplifies the physical, cognitive, and euphoric effects of MDMA. The visual, physical and cognitive effects of LSA can also be intensified to the point of overwhelming euphoric pleasure manifested through unique body highs, mindscapes, and colorful and intricate visuals. The synergy between these substances is unpredictable, and it is advised to start with markedly lower dosages than one would take for both substances individually. The toxicity of this combination is unknown, although there is some evidence that suggests the neurotoxic effects of MDMA may become amplified.<ref>Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023</ref><ref>Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine</ref><ref>Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501</ref>
 *'''[[Alcohol]]''' - This combination is not typically recommended due to alcohol’s ability to cause [[dehydration]] and [[nausea]] and [[physical fatigue]] which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, reasonably safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically draining way.
 *'''[[Benzodiazepines]]''' - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSA trip. They are very efficient at stopping [[bad trip|"bad trips"]] at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addictive potential that benzodiazepines possess.