LSA: Difference between revisions

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'''Lysergic acid amide''' (also known as '''ergine''', '''d-lysergic acid amide''', '''d-lysergamide''', and '''LSA''') is a [[naturally-occurring]] [[Psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. LSA is an ergot alkaloid and the main psychoactive constituent of ~~plants such as~~ [[LSA#Morning_glory_seeds_.28MGS.29|morning glory seeds]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose seeds]].{{citation needed}} LSA ~~has a similar chemical structure as~~ [[LSD]] and ~~shares some of its~~ effects.

'''Lysergic acid amide''' (also known as '''ergine''', '''d-lysergic acid amide''', '''d-lysergamide''', and '''LSA''') is a [[naturally-occurring]] [[Psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class.

LSA is an ergot [[alkaloid]] and the main psychoactive constituent of [[LSA#Morning_glory_seeds_.28MGS.29|morning glory seeds]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose seeds]].{{citation needed}}

LSA is chemically related to [[LSD]] and supposedly produces similar effects, although the extent to which this is true is unclear.

LSA was first described in 1932 as part of an investigation into ergot alkaloids. In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose ~~led to~~ a "tired, dreamy state with an inability to maintain clear thoughts." ~~After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.~~<ref>#26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml</ref>

LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot, a grain fungus.<ref>Smith, S., & Timmis, G. M. (1932). 98. The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine. Journal of the Chemical Society (Resumed), 763-766.</ref>

In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a "tired, dreamy state with an inability to maintain clear thoughts."<ref>#26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml</ref>

In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>Miller, M. D. (1970). Isolation and identification of lysergic acid amide and isolysergic acid amide as the principal ergoline alkaloids in Argyreia nervosa, a tropical wood rose. J AOAC, 53(1), 123-128.</ref>

Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds, both of which are legally obtainable in gardening stores.<ref>Borsutzky, M., Passie, T., Paetzold, W., Emrich, H. M., & Schneider, U. (2002). Hawaiian baby woodrose:(Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration. Der Nervenarzt, 73(9), 892-896.</ref>

Like other psychedelics, LSA is not considered to be addictive by the scientific community.<ref>Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437</ref> However, adverse reactions such as ~~uncontrollable~~ [[anxiety]], [[paranoia]], and [[psychosis]] is always possible, particularly among those who are predisposed to psychiatric disorders.<ref>Strassman, R. J. (1984). Adverse Reactions to Psychedelic Drugs: A Review of the Literature. ''The Journal of Nervous and Mental Disease'', 172(10), 577-595. PMID: 6384428</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.

User reports describe the effects of LSA as primarily sedating and dream-like with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as mainly physical and tactile with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") on LSA.

Like other psychedelics, LSA is not considered to be addictive by the scientific community.<ref>Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>Strassman, R. J. (1984). Adverse Reactions to Psychedelic Drugs: A Review of the Literature. ''The Journal of Nervous and Mental Disease'', 172(10), 577-595. PMID: 6384428</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

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|{{effects/physical|

*'''[[Effect::Sedation~~]]''' & '''[[Effect::Stimulation~~]]''' - LSA ~~tends to produce sedation~~; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.

*'''[[Effect::Sedation]]''' - LSA is predominantly sedating; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.

*'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of LSA can be described as a mild yet pleasurable and soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of [[physical euphoria]] which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. Compared to [[LSD]], the physical effects of [[LSA]] tend to predominate the experience relative to its visual and cognitive effects.

**'''[[Effect::Perception of bodily heaviness]]'''

@@ Line 2: / Line 2: @@
 {{SubstanceBox/LSA}}
-'''Lysergic acid amide''' (also known as '''ergine''', '''d-lysergic acid amide''', '''d-lysergamide''', and '''LSA''') is a [[naturally-occurring]] [[Psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. LSA is an ergot alkaloid and the main psychoactive constituent of plants such as [[LSA#Morning_glory_seeds_.28MGS.29|morning glory seeds]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose seeds]].{{citation needed}} LSA has a similar chemical structure as [[LSD]] and shares some of its effects.
+'''Lysergic acid amide''' (also known as '''ergine''', '''d-lysergic acid amide''', '''d-lysergamide''', and '''LSA''') is a [[naturally-occurring]] [[Psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class.
+LSA is an ergot [[alkaloid]] and the main psychoactive constituent of [[LSA#Morning_glory_seeds_.28MGS.29|morning glory seeds]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose seeds]].{{citation needed}}
+LSA is chemically related to [[LSD]] and supposedly produces similar effects, although the extent to which this is true is unclear.
-LSA was first described in 1932 as part of an investigation into ergot alkaloids. In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose led to a "tired, dreamy state with an inability to maintain clear thoughts." After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.<ref>#26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml</ref>
+LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot, a grain fungus.<ref>Smith, S., & Timmis, G. M. (1932). 98. The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine. Journal of the Chemical Society (Resumed), 763-766.</ref>
+In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a "tired, dreamy state with an inability to maintain clear thoughts."<ref>#26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml</ref>
+In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>Miller, M. D. (1970). Isolation and identification of lysergic acid amide and isolysergic acid amide as the principal ergoline alkaloids in Argyreia nervosa, a tropical wood rose. J AOAC, 53(1), 123-128.</ref>
+Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds, both of which are legally obtainable in gardening stores.<ref>Borsutzky, M., Passie, T., Paetzold, W., Emrich, H. M., & Schneider, U. (2002). Hawaiian baby woodrose:(Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration. Der Nervenarzt, 73(9), 892-896.</ref>
-Like other psychedelics, LSA is not considered to be addictive by the scientific community.<ref>Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437</ref> However, adverse reactions such as uncontrollable [[anxiety]], [[paranoia]], and [[psychosis]] is always possible, particularly among those who are predisposed to psychiatric disorders.<ref>Strassman, R. J. (1984). Adverse Reactions to Psychedelic Drugs: A Review of the Literature. ''The Journal of Nervous and Mental Disease'', 172(10), 577-595. PMID: 6384428</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.
+User reports describe the effects of LSA as primarily sedating and dream-like with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as mainly physical and tactile with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") on LSA.
+Like other psychedelics, LSA is not considered to be addictive by the scientific community.<ref>Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437</ref> However, adverse reactions such as severe [[anxiety]], [[paranoia]], and [[psychosis]] are always possible, particularly among those who are predisposed to psychiatric disorders.<ref>Strassman, R. J. (1984). Adverse Reactions to Psychedelic Drugs: A Review of the Literature. ''The Journal of Nervous and Mental Disease'', 172(10), 577-595. PMID: 6384428</ref> It is therefore highly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==
@@ Line 25: / Line 32: @@
 |{{effects/physical|
-*'''[[Effect::Sedation]]''' & '''[[Effect::Stimulation]]''' - LSA tends to produce sedation; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.
+*'''[[Effect::Sedation]]''' - LSA is predominantly sedating; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.
 *'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of LSA can be described as a mild yet pleasurable and soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of [[physical euphoria]] which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. Compared to [[LSD]], the physical effects of [[LSA]] tend to predominate the experience relative to its visual and cognitive effects.
 **'''[[Effect::Perception of bodily heaviness]]'''