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'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class. 2C-H belongs to the [[2C-x]] family of substituted phenethylamines. However, it does not have psychedelic properties and is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.
'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class. 2C-H belongs to the [[2C-x]] family of substituted phenethylamines. However, it does not have psychedelic properties and is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.


2C-H was first synthesized in 1932 by Johannes S. Buck<ref>Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.</ref> and its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].  
2C-H was first synthesized in 1932 by Johannes S. Buck.<ref>Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.</ref> Its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].  


In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.
In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.
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