3-MeO-PCP: Difference between revisions

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'''3-Methoxyphencyclidine''' (~~commonly~~ known as '''3-MeO-PCP~~''' or '''3-MeO~~''') is a lesser-known novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class ~~that produces~~ [[~~dissociative~~]]~~, [[pain relief|anesthetic]],~~ and ~~[[hallucinogenic]] effects when [[Routes of administration|administered]]. It~~ is ~~structurally~~ related to ~~[[arylcyclohexylamines]]~~ like [[~~PCP]], [[MXE~~]], and [[3-MeO-PCE]].

'''3-Methoxyphencyclidine''' (also known as '''3-MeO-PCP''') is a lesser-known novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. 3-MeO-PCP is a derivative of [[phencyclidine]] ('''PCP''') and is related to compounds like [[methoxetamine]] and [[3-MeO-PCE]].

3-MeO-PCP was first synthesized in 1979 ~~to investigate the structure-activity relationship~~ of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>

3-MeO-PCP was first synthesized in 1979 in an investigation of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>

Like other arylcyclohexlyamines, 3-MeO-PCP ~~is known to primarily induce~~ a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].

Like other arylcyclohexlyamines, 3-MeO-PCP induces a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].

~~Today,~~ 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.

3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.

==Chemistry==

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 {{SubstanceBox/3-MeO-PCP}}
-'''3-Methoxyphencyclidine''' (commonly known as '''3-MeO-PCP''' or '''3-MeO''') is a lesser-known novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class that produces [[dissociative]], [[pain relief|anesthetic]], and [[hallucinogenic]] effects when [[Routes of administration|administered]]. It is structurally related to [[arylcyclohexylamines]] like [[PCP]], [[MXE]], and [[3-MeO-PCE]].
+'''3-Methoxyphencyclidine''' (also known as '''3-MeO-PCP''') is a lesser-known novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. 3-MeO-PCP is a derivative of [[phencyclidine]] ('''PCP''') and is related to compounds like [[methoxetamine]] and [[3-MeO-PCE]].
--MeO-PCP was first synthesized in 1979 to investigate the structure-activity relationship of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>
+-MeO-PCP was first synthesized in 1979 in an investigation of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>
-Like other arylcyclohexlyamines, 3-MeO-PCP is known to primarily induce a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].
+Like other arylcyclohexlyamines, 3-MeO-PCP induces a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].
-Today, 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.
+-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.
 ==Chemistry==