3-MeO-PCP: Difference between revisions

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3-MeO-PCP was first synthesized in 1979 to investigate the structure-activity relationship of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>

Like other ~~substances of its class~~, ~~particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[~~3-MeO-~~PCE]], it~~ is known to primarily induce a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].

Like other arylcyclohexlyamines, 3-MeO-PCP is known to primarily induce a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].

Today, 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.

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==Subjective effects==

3-MeO-PCP ~~can be said to feel considerably~~ more stimulating and less immobilizing than other [[dissociatives]] such as [[ketamine]] or [[MXE]]. At lower doses, it can induce sensory enhancements such as [[color enhancement]], [[acuity enhancement]], [[tactile enhancement]], [[auditory enhancement]] and [[bodily control enhancement]]. However, at medium to high doses, it presents sensory suppressions such as [[tactile suppression]], [[motor control loss]], [[auditory suppression]] and [[acuity suppression]]. Based on a large amount of experience reports, it appears to be considerably more likely to induce [[mania]], [[delusions]], and [[psychosis]] than other dissociatives (possibly due to its unusually high potency, [[compulsive redosing|compulsivity]] and erratic dose response).

3-MeO-PCP is commonly described as being more stimulating and less immobilizing than other [[dissociatives]] such as [[ketamine]] or [[MXE]]. At lower doses, it can induce sensory enhancements such as [[color enhancement]], [[acuity enhancement]], [[tactile enhancement]], [[auditory enhancement]] and [[bodily control enhancement]]. However, at medium to high doses, it presents sensory suppressions such as [[tactile suppression]], [[motor control loss]], [[auditory suppression]] and [[acuity suppression]]. Based on a large amount of experience reports, it appears to be considerably more likely to induce [[mania]], [[delusions]], and [[psychosis]] than other dissociatives (possibly due to its unusually high potency, [[compulsive redosing|compulsivity]] and erratic dose response).

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*'''[[Effect::Stimulation]]''' - This substance is regarded to be noticeably stimulating in comparison to other dissociatives such as [[ketamine]], [[MXE]], or [[DCK]]. The stimulation it presents is clean and comfortable in a manner which is far closer to that of [[3-MeO-PCE]] than that of [[O-PCE]].

**'''[[Effect::Perception of bodily lightness]]'''

*'''[[Effect::Perception of bodily lightness]]'''

**'''[[Effect::Restless legs]]'''

*'''[[Effect::Restless legs]]'''

*'''[[Effect::Spontaneous ~~physical~~ sensations]]''' - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.

*'''[[Effect::Spontaneous bodily sensations]]''' - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.

**'''[[Effect::Physical euphoria]]''' - 3-MeO-PCP has been reported to more readily induce euphoria than most other dissociatives, such as [[ketamine]] or [[diphenidine]], especially of the manic variant.

*'''[[Effect::Physical euphoria]]''' - 3-MeO-PCP has been reported to more readily induce euphoria than most other dissociatives, such as [[ketamine]] or [[diphenidine]], especially of the manic variant.

*'''[[Effect::Tactile enhancement]]''' or '''[[Effect::Tactile suppression]]''' - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and [[pain relief|anesthesia]].

*'''[[Effect::Pain relief]]''' - This substance produces distinct nerve-signal blocking anesthetic effects typically required in surgical settings, but only in the stronger to heavier dose ranges.

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==Legal status==

*'''Austria''' - 3-~~Meo~~-PCP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).

*'''Austria:''' 3-MeO-PCP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).{{citation needed}}

*'''Germany:''' On November 21, 2015, 3-MeO-PCP was added to "Anlage II" of the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.<ref>30. BtMÄndVO in Kraft getreten | http://blog.beck.de/2015/11/23/30-btm-ndvo-in-kraft-getreten-6-neue-stoffe-wurden-ins-btmg-aufgenommen-0</ref>

*'''Sweden:''' Sweden's public health agency suggested classifying 3-MeO-PCP as a hazardous substance on November 10, 2014.<ref>Cannabinoider föreslås bli klassade som hälsofarlig vara | http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/</ref>

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*[https://isomerdesign.com/PiHKAL/explore.php?id=11015 3-MeO-PCP (Isomer Design)]

===~~Community~~===

===Discussion and media===

*[http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2 The Big & Dandy 3-MeO-PCP Thread (Bluelight)]

*[https://web.archive.org/web/20170111011440*/https://www.vice.com/en_us/article/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist (VICE)]

==Literature==

* Morris, H., & Wallach, J. (2014). ~~'''''~~From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs.~~''''' ''~~Drug Testing and Analysis'', 6(7–8), 614–632. https://doi.org/10.1002/dta.1620

* Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620

==References==

@@ Line 7: / Line 7: @@
 -MeO-PCP was first synthesized in 1979 to investigate the structure-activity relationship of [[phencyclidine]] (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to [[PCP]] along with comparable potency.<ref name="PCP2MXE">Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>
-Like other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is known to primarily induce a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].
+Like other arylcyclohexlyamines, 3-MeO-PCP is known to primarily induce a state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]", although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken [[orally]] and [[nasally]], although it may also be [[smoked]] and [[injected]]. It has been noted for its subtle come up and tendency to produce [[Delusions#Delusion of sobriety|delusions of sobriety]], which can lead to [[compulsive redosing]].
 Today, 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area [[research chemical]] through the use of online vendors<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref>, where it is commonly used as a [[recreational drug use|recreational substance]] and, more rarely and controversially, as an [[entheogen]].{{citation needed}} Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if using this substance.
@@ Line 27: / Line 27: @@
 ==Subjective effects==
--MeO-PCP can be said to feel considerably more stimulating and less immobilizing than other [[dissociatives]] such as [[ketamine]] or [[MXE]]. At lower doses, it can induce sensory enhancements such as [[color enhancement]], [[acuity enhancement]], [[tactile enhancement]], [[auditory enhancement]] and [[bodily control enhancement]]. However, at medium to high doses, it presents sensory suppressions such as [[tactile suppression]], [[motor control loss]], [[auditory suppression]] and [[acuity suppression]]. Based on a large amount of experience reports, it appears to be considerably more likely to induce [[mania]], [[delusions]], and [[psychosis]] than other dissociatives (possibly due to its unusually high potency, [[compulsive redosing|compulsivity]] and erratic dose response).
+-MeO-PCP is commonly described as being more stimulating and less immobilizing than other [[dissociatives]] such as [[ketamine]] or [[MXE]]. At lower doses, it can induce sensory enhancements such as [[color enhancement]], [[acuity enhancement]], [[tactile enhancement]], [[auditory enhancement]] and [[bodily control enhancement]]. However, at medium to high doses, it presents sensory suppressions such as [[tactile suppression]], [[motor control loss]], [[auditory suppression]] and [[acuity suppression]]. Based on a large amount of experience reports, it appears to be considerably more likely to induce [[mania]], [[delusions]], and [[psychosis]] than other dissociatives (possibly due to its unusually high potency, [[compulsive redosing|compulsivity]] and erratic dose response).
 {{Preamble/SubjectiveEffects}}
@@ Line 35: / Line 35: @@
 *'''[[Effect::Stimulation]]''' - This substance is regarded to be noticeably stimulating in comparison to other dissociatives such as [[ketamine]], [[MXE]], or [[DCK]]. The stimulation it presents is clean and comfortable in a manner which is far closer to that of [[3-MeO-PCE]] than that of [[O-PCE]].
-**'''[[Effect::Perception of bodily lightness]]'''
+*'''[[Effect::Perception of bodily lightness]]'''
-**'''[[Effect::Restless legs]]'''
+*'''[[Effect::Restless legs]]'''
-*'''[[Effect::Spontaneous physical sensations]]''' - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.
+*'''[[Effect::Spontaneous bodily sensations]]''' - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.
-**'''[[Effect::Physical euphoria]]''' - 3-MeO-PCP has been reported to more readily induce euphoria than most other dissociatives, such as [[ketamine]] or [[diphenidine]], especially of the manic variant.
+*'''[[Effect::Physical euphoria]]''' - 3-MeO-PCP has been reported to more readily induce euphoria than most other dissociatives, such as [[ketamine]] or [[diphenidine]], especially of the manic variant.
 *'''[[Effect::Tactile enhancement]]''' or '''[[Effect::Tactile suppression]]''' - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and [[pain relief|anesthesia]].
 *'''[[Effect::Pain relief]]''' - This substance produces distinct nerve-signal blocking anesthetic effects typically required in surgical settings, but only in the stronger to heavier dose ranges.
@@ Line 168: / Line 168: @@
 ==Legal status==
 {{legalStub}}
-*'''Austria''' - 3-Meo-PCP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
+*'''Austria:''' 3-MeO-PCP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).{{citation needed}}
 *'''Germany:''' On November 21, 2015, 3-MeO-PCP was added to "Anlage II" of the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.<ref>30. BtMÄndVO in Kraft getreten | http://blog.beck.de/2015/11/23/30-btm-ndvo-in-kraft-getreten-6-neue-stoffe-wurden-ins-btmg-aufgenommen-0</ref>
 *'''Sweden:''' Sweden's public health agency suggested classifying 3-MeO-PCP as a hazardous substance on November 10, 2014.<ref>Cannabinoider föreslås bli klassade som hälsofarlig vara | http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/</ref>
@@ Line 187: / Line 187: @@
 *[https://isomerdesign.com/PiHKAL/explore.php?id=11015 3-MeO-PCP (Isomer Design)]
-===Community===
+===Discussion and media===
 *[http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2 The Big & Dandy 3-MeO-PCP Thread (Bluelight)]
 *[https://web.archive.org/web/20170111011440*/https://www.vice.com/en_us/article/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist (VICE)]
 ==Literature==
-* Morris, H., & Wallach, J. (2014). '''''From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs.''''' ''Drug Testing and Analysis'', 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
+* Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
 ==References==