Salvinorin A: Difference between revisions

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==Pharmacology==

Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT2A receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. ~~Salvia's~~ unique structure lacks features commonly associated with opioid ligand binding such as a quaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.

Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT2A receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. The unique structure of salvinorin A lacks features commonly associated with opioid ligand binding such as a quaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.

Salvinorin A also acts as a potent agonist at [[dopamine|D2]] receptors,<ref>https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.

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 ==Pharmacology==
-Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT<sub>2A</sub> receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. Salvia's unique structure lacks features commonly associated with opioid ligand binding such as a quaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.
+Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT<sub>2A</sub> receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. The unique structure of salvinorin A lacks features commonly associated with opioid ligand binding such as a quaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.
 Salvinorin A also acts as a potent agonist at [[dopamine|D<sub>2</sub>]] receptors,<ref>https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20647</ref> which may be partially responsible for its hallucinogenic effects.